Serum differentially alters the antifungal properties of echinocandin drugs

被引：91

作者：

Paderu, Padmaja ^{[1
]}

Garcia-Effron, Guillermo ^{[1
]}

Balashov, Sergey ^{[1
]}

Delmas, Guillaume ^{[1
]}

Park, Steven ^{[1
]}

Perlin, David S. ^{[1
]}

机构：

[1] Publ Hlth Res Inst, Newark, NJ 07103 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 06期

关键词：

D O I：

10.1128/AAC.01536-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antifungal efficacies of the echinocandin drugs caspofungin, micafungin, and anidulafungin were reduced significantly in the presence of 50% human serum, which yielded nearly equivalent MICs or minimum effective concentrations against diverse Candida spp. and Aspergillus spp. Consistent with a direct drug interaction, ser-um decreased the sensitivity of glucan synthase to echinocandin drugs.

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页码：2253 / 2256

页数：4

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