Matrix metalloproteinases and the gut - new roles for old enzymes

被引：75

作者：

Pender, SL ^{[1
]}

MacDonald, TT ^{[1
]}

机构：

[1] Univ Southampton, Sch Med, Div Infect Inflammat & Repair, Southampton SO16 6YD, Hants, England

来源：

CURRENT OPINION IN PHARMACOLOGY | 2004年 / 4卷 / 06期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/j.coph.2004.06.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Matrix metalloproteinases (MMPs) are a family of neutral proteases with the ability to degrade all components of extracellular matrix. To date, more than 24 different human MMPs have been identified. MMP activity is important in diseases such as arthritis, atherosclerosis, periodontal diseases and cancer. Recent data suggest that MMPs are involved in tissue injury and healing in the human gut.

引用

页码：546 / 550

页数：5

共 49 条

[1] FECAL ELASTASE REFLECTS DISEASE-ACTIVITY IN ACTIVE ULCERATIVE-COLITIS [J].

ADEYEMI, EO ;

HODGSON, HJF .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1992, 27 (02) :139-142

[2] Extracellular matrix composition and gene expression in collagenous colitis [J].

Aigner, T ;

Neureiter, D ;

Muller, S ;

Kuspert, G ;

Belke, J ;

Kirchner, T .

GASTROENTEROLOGY, 1997, 113 (01) :136-143

[3] Vascular smooth muscle cells and pericytes express MMP-1, MMP-9, TIMP-1 and type I procollagen in inflammatory bowel disease [J].

Arihiro, S ;

Ohtani, H ;

Hiwatashi, N ;

Torii, A ;

Sorsa, T ;

Nagura, H .

HISTOPATHOLOGY, 2001, 39 (01) :50-59

[4] Matrix metalloproteinase-3 secretion from human colonic subepithelial myofibroblasts: role of interleukin-17 [J].

Bamba, S ;

Andoh, A ;

Yasui, H ;

Araki, Y ;

Bamba, T ;

Fujiyama, Y .

JOURNAL OF GASTROENTEROLOGY, 2003, 38 (06) :548-554

[5] The regulation of matrix metalloproteinase production in human colonic fibroblasts [J].

Baugh, MD ;

Hollander, AP ;

Evans, GS .

INTESTINAL PLASTICITY IN HEALTH AND DISEASE, 1998, 859 :175-179

[6] Budesonide treatment of collagenous colitis: a randomised, double blind, placebo controlled trial with morphometric analysis [J].

Bonderup, OK ;

Hansen, JB ;

Birket-Smith, L ;

Vestergaard, V ;

Teglbjaerg, PS ;

Fallingborg, J .

GUT, 2003, 52 (02) :248-251

[7] Tissue inhibitors of metalloproteinases: evolution, structure and function [J].

Brew, K ;

Dinakarpandian, D ;

Nagase, H .

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 2000, 1477 (1-2) :267-283

[8] Timeline - Matrix metalloproteinases: a tail of a frog that became a prince [J].

Brinckerhoff, CE ;

Matrisian, LM .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (03) :207-214

[9] Helicobacter pylori strain-selective induction of matrix metalloproteinase-7 in vitro and within gastric mucosa [J].

Crawford, HC ;

Krishna, LS ;

Israel, DA ;

Matrisian, LM ;

Washington, MK ;

Peek, RM .

GASTROENTEROLOGY, 2003, 125 (04) :1125-1136

[10] Increased expression of mRNA for matrix metalloproteinases-1 and -3 and tissue inhibitor of metalloproteinases-1 in intestinal biopsy specimens from patients with coeliac disease [J].

Daum, S ;

Bauer, U ;

Foss, HD ;

Schuppan, D ;

Stein, H ;

Riecken, EO ;

Ullrich, R .

GUT, 1999, 44 (01) :17-25

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