The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer

被引：33

作者：

Zogopoulous, George

Rothenmund, Heidi

Eppel, Ayelet

Ash, Colleen

Akbari, Mohammad Reza

Hedley, David

Narod, Steven A.

Gallinger, Steven

机构：

[1] Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada

[2] Samuel Lunenfeld Res Inst, Sam Minuk Canc Genet & Biomarker Labs, Toronto, ON, Canada

[3] Univ Toronto, Womens Coll Res Inst, Toronto, ON, Canada

[4] Univ Toronto, Princess Margaret Hosp, Ontario Canc Inst, Dept Med Oncol & Hematol, Toronto, ON, Canada

[5] Univ Toronto, Princess Margaret Hosp, Ontario Canc Inst, Div Expt Therapeut, Toronto, ON, Canada

来源：

HUMAN GENETICS | 2007年 / 121卷 / 05期

关键词：

D O I：

10.1007/s00439-007-0361-z

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The P239S palladin variant has recently been suggested to play a role in hereditary pancreatic cancer. We estimated the contribution of the P239S variant, and surrounding sequence, to familial and early-onset pancreatic cancer. The P239S germline variant was identified in one of 84 high-risk cases and one of 555 controls. The case reported an elderly relative with pancreas cancer. We conclude that this variant does not appear to account for a significant fraction of hereditary or early-onset pancreas cancer.

引用

页码：635 / 637

页数：3

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