Global Mapping of Herpesvirus-Host Protein Complexes Reveals a Transcription Strategy for Late Genes

被引：159

作者：

Davis, Zoe H. ^{[1
,2
]}

Verschueren, Erik ^{[3
,4
]}

Jang, Gwendolyn M. ^{[3
,4
]}

Kleffman, Kevin ^{[1
]}

Johnson, Jeffrey R. ^{[3
,4
]}

Park, Jimin ^{[1
]}

Von Dollen, John ^{[3
,4
]}

Maher, M. Cyrus ^{[5
,6
]}

Johnson, Tasha ^{[3
,4
]}

Newton, William ^{[3
,4
]}

Jaeger, Stefanie ^{[3
,4
]}

Shales, Michael ^{[3
,4
]}

Horner, Julie ^{[7
]}

Hernandez, Ryan D. ^{[6
]}

Krogan, Nevan J. ^{[3
,4
]}

Glaunsinger, Britt A. ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Plant & Microbial Biol, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Sch Publ Hlth, Div Infect Dis & Immun, Berkeley, CA 94720 USA

[3] Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94158 USA

[4] Univ Calif San Francisco, Gladstone Inst, San Francisco, CA 94158 USA

[5] Univ Calif San Francisco, Inst Human Genet, San Francisco, CA 94158 USA

[6] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94158 USA

[7] Thermo Fisher Sci, San Jose, CA 95134 USA

来源：

MOLECULAR CELL | 2015年 / 57卷 / 02期

关键词：

RNA-POLYMERASE-II; EPSTEIN-BARR-VIRUS; DNA-REPLICATION; ENDOTHELIAL ORIGIN; VIRAL REPLICATION; CELL-LINE; EXPRESSION; PROMOTER; NETWORK; TYPE-1;

D O I：

10.1016/j.molcel.2014.11.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mapping host-pathogen interactions has proven instrumental for understanding how viruses manipulate host machinery and how numerous cellular processes are regulated. DNA viruses such as herpesviruses have relatively large coding capacity and thus can target an extensive network of cellular proteins. To identify the host proteins hijacked by this pathogen, we systematically affinity tagged and purified all 89 proteins of Kaposi's sarcoma-associated herpesvirus (KSHV) from human cells. Mass spectrometry of this material identified over 500 virus-host interactions. KSHV causes AIDS-associated cancers, and its interaction network is enriched for proteins linked to cancer and overlaps with proteins that are also targeted by HIV-1. We found that the conserved KSHV protein ORF24 binds to RNA polymerase II and brings it to viral late promoters by mimicking and replacing cellular TATA-box-binding protein (TBP). This is required for herpesviral late gene expression, a complex and poorly understood phase of the viral lifecycle.

引用

页码：349 / 360

页数：12

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