Enantioselective synthesis of a benzofuranic neolignan by oxidative coupling

被引：42

作者：

Bolzacchini, E

Brunow, G

Meinardi, S

Orlandi, M

Rindone, B

Rummakko, P

Setala, H

机构：

[1] Univ Milan, Dept Environm Sci, I-20126 Milan, Italy

[2] Univ Helsinki, Dept Chem, FIN-00014 Helsinki, Finland

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 20期

关键词：

D O I：

10.1016/S0040-4039(98)00473-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first stereoselective free radical coupling of a phenylpropenoidic phenolic compound is reported. The oxidation of a chiral ferulic acid amide to give dimeric benzofuranic neolignan is performed enzymatically using horseradish peroxidase as the catalyst. Enantiomeric excess in a biologically active compound with phenylcoumaran skeleton (beta-5 dimer) is thus obtained. (C) 1998 Elsevier Science Ltd. Ail rights reserved.

引用

页码：3291 / 3294

页数：4

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