Selective effects on NGFI-A, MR, GR and NGFI-B hippocampal mRNA expression after chronic treatment with different subclasses of antidepressants in the rat

被引:59
作者
Bjartmar, L [1 ]
Johansson, IM
Marcusson, J
Ross, SB
Seckl, JR
Olsson, T
机构
[1] Linkoping Univ Hosp, Dept Neurosci & Locomot, Div Geriatr Med, S-58185 Linkoping, Sweden
[2] Univ Umea Hosp, Dept Publ Hlth & Clin Med, S-90185 Umea, Sweden
[3] Univ Umea Hosp, Dept Clin Sci Obstet & Gynecol, S-90185 Umea, Sweden
[4] Astra Arcus AB, Sodertalje, Sweden
[5] Univ Edinburgh, Western Gen Hosp, Mol Med Ctr, Edinburgh, Midlothian, Scotland
基金
英国惠康基金;
关键词
NGFI-A; NGFI-B; glucocorticoid receptor; antidepressant drug; transcription factor;
D O I
10.1007/s002130000468
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
There is a latency period of several weeks before the onset of clinical effect of antidepressant drugs. The detailed mechanisms underlying drug-induced adaptive neuronal changes are not known. To elucidate the involvement of changes in gene expression of candidate transcription factors, we treated rats for 21 days with buspirone, fluoxetine, 8-OH-DPAT and moclobemide. In situ hybridization was used to study mRNAs encoding NGFI-A, NGFI-B and the glucocorticoid receptors, MR and GR. NGFI-A mRNA expression increased profoundly in the hippocampal formation and the cerebral cortex after all drug treatments, especially after moclobemide treatment (77-122% increase), with the exception of buspirone. MR mRNA expression was induced in hippocampal CA1/CA2 subregions (27-37%) by all antidepressants, while moclobemide and 8-OH-DPAT significantly increased GR gene expression mainly in the CA1 region (31-44%). NGFI-B mRNA was significantly decreased in the hippocampal CA3 subfield (23%) and restrosplenial granular cortex (38%) by moclobemide treatment. There ale selective effects of antidepressant drugs on specific transcription factors. These may be important fur adaptive neuronal and neuroendocrine changes after antidepressant treatment including HPA axis negative feedback regulation.
引用
收藏
页码:7 / 12
页数:6
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