Prevalence of CCR5 and CCR2 HIV-coreceptor gene polymorphisms in Belgium

被引：26

作者：

Struyf, F

Thoelen, I

Charlier, N

Keyaerts, E

Van der Donck, I

Wuu, J

Van Ranst, M

机构：

[1] Rega Inst Med Res, Dept Microbiol & Immunol, Virol Lab, B-3000 Louvain, Belgium

[2] Univ Massachusetts, Ctr Canc, Div Biostat & Epidemiol, Worcester, MA 01605 USA

来源：

HUMAN HEREDITY | 2000年 / 50卷 / 05期

关键词：

CCR5; CCR2; chemokine receptors; polymorphism; HIV; acquired immunodeficiency syndrome; Belgium;

D O I：

10.1159/000022932

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Polymorphisms of the chemokine receptor genes CCR5 and CCR2 are associated with resistance to HIV-1 infection or delayed progression to AIDS. Few data are available on their combined prevalence in healthy subjects; we therefore examined the occurrence of CCR5-Delta 32 and CCR2-641 polymorphisms in a sample of 310 healthy Belgians. Allele frequencies were 0.119 and 0.074 for CCR5-Delta 32 and CCR2-641, respectively, Genotype distributions for both polymorphisms were found to be in accordance with Hardy-Weinberg equilibrium, but a significant (p = 0.002) linkage disequilibrium between CCR5-Delta 32 and CCR2-641 was observed. The high prevalence of CCR5-Delta 32 and CCR2-641 in Belgians may need to be taken into account in the design of studies of antiretroviral treatments, Copyright (C) 2000 S. Karger AG, Basel.

引用

页码：304 / 307

页数：4

共 13 条

[1] Association between CCR5 genotype and the clinical course of HIV-1 infection [J].

Husman, AMD ;

Koot, M ;

Cornelissen, M ;

Keet, IPM ;

Brouwer, M ;

Broersen, SM ;

Bakker, M ;

Roos, MTL ;

Prins, M ;

deWolf, F ;

Coutinho, RA ;

Miedema, F ;

Goudsmit, J ;

Schuitemaker, H .

ANNALS OF INTERNAL MEDICINE, 1997, 127 (10) :882-+

[2] A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation [J].

Kostrikis, LG ;

Huang, YX ;

Moore, JP ;

Wolinsky, SM ;

Zhang, LQ ;

Guo, Y ;

Deutsch, L ;

Phair, J ;

Neumann, AU ;

Ho, DD .

NATURE MEDICINE, 1998, 4 (03) :350-353

[3]

LENCH N, 1988, LANCET, V1, P1356

[4] The Δccr5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in Northeastern Europe [J].

Libert, F ;

Cochaux, P ;

Beckman, G ;

Samson, M ;

Aksenova, M ;

Cao, A ;

Czeizel, A ;

Claustres, M ;

de la Rua, C ;

Ferrari, M ;

Ferrec, C ;

Glover, G ;

Grinde, B ;

Güran, S ;

Kucinskas, V ;

Lavinha, J ;

Mercier, B ;

Ogur, G ;

Peltonen, L ;

Rosatelli, C ;

Schwartz, M ;

Spitsyn, V ;

Timar, L ;

Beckman, L ;

Parmentier, M ;

Vassart, G .

HUMAN MOLECULAR GENETICS, 1998, 7 (03) :399-406

[5] Frequency of CCR5 genotypes in HIV-infected patients in Roraima, Brazil [J].

Guerra Corado, Andre de Lima ;

Villarouco da Silva, George Allan ;

Carvalho Leao, Renato Augusto ;

Granja, Fabiana ;

Naveca, Felipe Gomes .

BRAZILIAN JOURNAL OF INFECTIOUS DISEASES, 2016, 20 (03) :314-315

[6] Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term nonprogressor status in human immunodeficiency virus-1-infected individuals [J].

Magierowska, M ;

Theodorou, L ;

Debré, P ;

Sanson, F ;

Autran, B ;

Rivière, Y ;

Charron, D ;

Alt, F ;

Costagliola, D .

BLOOD, 1999, 93 (03) :936-941

[7] CCR2-64I polymorphism is not associated with altered CCR5 expression or coreceptor function [J].

Mariani, R ;

Wong, S ;

Mulder, LCF ;

Wilkinson, DA ;

Reinhart, AL ;

LaRosa, G ;

Nibbs, R ;

O'Brien, TR ;

Michael, NL ;

Connor, RI ;

Macdonald, M ;

Busch, M ;

Koup, RA ;

Landau, NR .

JOURNAL OF VIROLOGY, 1999, 73 (03) :2450-2459

[8] Genetic acceleration of AIDS progression by a promoter variant of CCR5 [J].

Martin, MP ;

Dean, M ;

Smith, MW ;

Winkler, C ;

Gerrard, B ;

Michael, NL ;

Lee, B ;

Doms, RW ;

Margolick, J ;

Buchbinder, S ;

Goedert, JJ ;

O'Brien, TR ;

Hilgartner, MW ;

Vlahov, D ;

O'Brien, SJ ;

Carrington, M .

SCIENCE, 1998, 282 (5395) :1907-1911

[9] Global distribution of the CCR5 gene 32-basepair deletion [J].

Martinson, JJ ;

Chapman, NH ;

Rees, DC ;

Liu, YT ;

Clegg, JB .

NATURE GENETICS, 1997, 16 (01) :100-103

[10] Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene [J].

Samson, M ;

Libert, F ;

Doranz, BJ ;

Rucker, J ;

Liesnard, C ;

Farber, CM ;

Saragosti, S ;

Lapoumeroulie, C ;

Cognaux, J ;

Forceille, C ;

Muyldermans, G ;

Verhofstede, C ;

Burtonboy, G ;

Georges, M ;

Imai, T ;

Rana, S ;

Yi, YJ ;

Smyth, RJ ;

Collman, RG ;

Doms, RW ;

Vassart, G ;

Parmentier, M .

NATURE, 1996, 382 (6593) :722-725

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