Short enantioselective approach to substituted triazolopyridazines from [(S)R]-1-(1E,3E)-1-p-tolylsulfinyl-1,3-pentadiene

被引：16

作者：

Carreño, MC ^{[1
]}

Cid, MB

Ruano, JLG

Santos, M

机构：

[1] Univ Autonoma, Dept Quim Organ CI, Madrid 28049, Spain

[2] Univ Valladolid, Dept Quim Organ, ETSIL, Valladolid 47011, Spain

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 11期

关键词：

D O I：

10.1016/S0040-4039(97)10776-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantiomerically pure hydroxy substituted triazolopyridazine 5a was obtained in one pot under mild conditions by reaction of (+)-(R)-(1E,3E)-1-(p-tolylsulfinyl)-1,3-pentadiene and 4-methyl-1,2,4-triazoline-3,5-dione in the presence of P(OMe)(3). The process involved a tandem Diels-Alder cycloaddition/sulfoxide-sulfenate rearrangement and trapping of the intermediate sulfenate. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1405 / 1408

页数：4

共 18 条

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