Direct, efficient and selective tritiations of paclitaxel and photoaffinity taxoids

被引：17

作者：

Shu, AYL ^{[1
]}

Heys, JR ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Dept Synthet Chem, Radiochem Sect, King Of Prussia, PA 19406 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 47期

关键词：

organoiridum-mediated tritium exchange; paclitaxel; photoaffinity taxoids; Crabtree's catalyst;

D O I：

10.1016/S0040-4039(00)01652-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Radiolabeled paclitaxel and three photophore-bearing derivatives were prepared by organoiridium-mediated direct tritium exchange under both catalytic and stoichiometric conditions. The resulting tritiated taxoids had specific activities ranging from 53 to 195 Ci/mmol. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9015 / 9019

页数：5

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