Predictable αβ T-cell receptor selection toward an HLA-B*3501-Restricted human cytomegalovirus epitope

被引：16

作者：

Brennan, Rebekah M.

Miles, John J.

Silins, Sharon L.

Bell, Melissa J.

Burrows, Jacqueline M.

Burrows, Scott R.

机构：

[1] Queensland Inst Med Res, Cellular Immunol Lab, Brisbane, Qld 4029, Australia

[2] Queensland Inst Med Res, Australian Ctr Vaccine Dev, Brisbane, Qld 4029, Australia

[3] Univ Queensland, Sch Populat Hlth, Brisbane, Qld, Australia

来源：

JOURNAL OF VIROLOGY | 2007年 / 81卷 / 13期

关键词：

D O I：

10.1128/JVI.00356-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human cytomegalovirus (HCMV) elicits a very large burden on the immune system, with approximately one in ten T cells being reserved solely to manage this infection. However, information on the clonotypic composition of these vast T-cell populations is limited. In this study, we sequenced 116 T-cell receptor (TcR) alpha/beta-chains specific for the highly immunogenic HLA-B*3501-resticted epitope IPSINVHHY from the pp65 antigen. Interestingly, T cells recovered from all donors bore an identical or near-identical TRBV28/TRBJ14/TRAV17/TRAJ33 TcR. The ability to predict the responding alpha beta TcR repertoire before viral infection should prove a powerful tool for basic and clinical immunology.

引用

收藏

页码：7269 / 7273

页数：5

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