Novel stereoselective construction of a quaternary carbon: application to synthesis of the cyclopentenedione moiety of madindolines

被引：63

作者：

Hosokawa, S ^{[1
]}

Sekiguchi, K ^{[1
]}

Enemoto, M ^{[1
]}

Kobayashi, S ^{[1
]}

机构：

[1] Sci Univ Tokyo, Fac Pharmaceut Sci, Shinjuku Ku, Tokyo 1620826, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 33期

关键词：

madindoline; cyclopentenedione; alkylation; quaternary carbon;

D O I：

10.1016/S0040-4039(00)00937-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective synthesis of the cyclopentenedione moiety of madindolines was achieved. Stereoselective construction of a quaternary carbon was realized by alkylation of an enolate possessing chiral auxiliary. Cyclopentenedione was derived from a triketone precursor by intramolecular condensation. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：6429 / 6433

页数：5

共 12 条

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