Diversity in single- and multiple-component crystals. The search for and prevalence of polymorphs and cocrystals

被引：443

作者：

Stahly, G. Patrick ^{[1
]}

机构：

[1] Aptuit Co, SSCI, W Lafayette, IN 47906 USA

来源：

CRYSTAL GROWTH & DESIGN | 2007年 / 7卷 / 06期

关键词：

D O I：

10.1021/cg060838j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A detailed description of polymorph screening procedures is presented. On the basis of the results of 245 polymorph screens, organic compounds were found to exist in multiple solid forms quite frequently. About 90% exhibited multiple crystalline and noncrystalline forms; about 50% exhibited polymorphism. Cocrystals are defined, and cocrystal screening is discussed. Data from 64 cocrystal screens show that cocrystals were found in 61% of the cases, and the total number of cocrystals found was 192.

引用

页码：1007 / 1026

页数：20

共 144 条

[1] The C-H•••Cl hydrogen bond:: Does it exist? [J].