Serum TNF-alpha levels are increased and correlate negatively with free IGF-I in Alzheimer disease

被引：218

作者：

Alvarez, Anton ^{[1
]}

Cacabelos, Ramon

Sanpedro, Carolina

Garcia-Fantini, Manuel

Aleixandre, Manuel

机构：

[1] EuroEspes Biomed Res Ctr, Dept Neuropharmacol, La Coruna 15166, Spain

[2] Hosp Juan Canalejo, Serv Neurocirugia, La Coruna 15006, Spain

[3] Univ Granada, Fac Psicol, E-18071 Granada, Spain

来源：

NEUROBIOLOGY OF AGING | 2007年 / 28卷 / 04期

关键词：

Alzheimer's disease; mild cognitive impairment; tumor necrosis factor-alpha; insulin-like growth factor-I; elderly control subjects;

D O I：

10.1016/j.neurobiolaging.2006.02.012

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Tumor necrosis factor-alpha (TNF-alpha) and insulin-like growth factor-I (IGF-I) have been involved in the pathogenesis of Alzheimer's disease (AD) as neurotoxic and survival factors, respectively. Recent experimental studies suggest that the signalling pathways of TNF-alpha and IGF-I are functionally interrelated. In order to investigate the possible interaction of TNF-alpha and IGF-I in AD and mild cognitive impairment (MCI), the serum levels of total IGF-I, free IGF-I and TNF-alpha were determined in 141 AD patients, 56 MCI cases and 30 controls. As compared with controls, AD patients showed increased TNF-alpha and decreased IGF-I levels in serum, as well as a significant negative correlation between TNF-alpha and free IGF-I values. MCI patients also exhibited significantly higher TNF-alpha levels than controls. The present results suggest that increased TNF-alpha levels are involved in the pathogenesis of AD and MCI, and might antagonize the neurotrophic activity of IGF-I in these medical conditions. In addition, the combined determination of TNF-alpha and IGF-I might be useful to monitor anti-inflammatory and/or neurotrophic drug effects in AD. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：533 / 536

页数：4

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