Long noncoding RNAs in cancer: mechanisms of action and technological advancements

被引：380

作者：

Bartonicek, Nenad ^{[1
]}

Maag, Jesper L. V. ^{[1
,2
]}

Dinger, Marcel E. ^{[1
,2
]}

机构：

[1] Garvan Inst Med Res, Genome Informat Genom & Epigenet Div, Sydney, NSW, Australia

[2] Univ New S Wales, St Vincents Clin Sch, Fac Med, Sydney, NSW, Australia

来源：

MOLECULAR CANCER | 2016年 / 15卷

关键词：

TUMOR-SUPPRESSOR; COLORECTAL-CANCER; PROTEIN INTERACTIONS; INDUCED APOPTOSIS; GENOMIC ANALYSIS; PROSTATE-CANCER; GENE-EXPRESSION; SINGLE-CELL; CHROMATIN; LNCRNA;

D O I：

10.1186/s12943-016-0530-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The previous decade has seen long non-coding RNAs (lncRNAs) rise from obscurity to being defined as a category of genetic elements, leaving its mark on the field of cancer biology. With the current number of curated lncRNAs increasing by 10,000 in the last five years, the field is moving from annotation of lncRNA expression in various tumours to understanding their importance in the key cancer signalling networks and characteristic behaviours. Here, we summarize the previously identified as well as recently discovered mechanisms of lncRNA function and their roles in the hallmarks of cancer. Furthermore, we identify novel technologies for investigation of lncRNA properties and their function in carcinogenesis, which will be important for their translation to the clinic as novel biomarkers and therapeutic targets.

引用

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