Surfing on a retrograde wave: how does Shiga toxin reach the endoplasmic reticulum?

被引：90

作者：

Johannes, L ^{[1
]}

Goud, B ^{[1
]}

机构：

[1] Inst Curie, UMR 144, F-75248 Paris 05, France

来源：

TRENDS IN CELL BIOLOGY | 1998年 / 8卷 / 04期

关键词：

D O I：

10.1016/S0962-8924(97)01209-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Bacterial Shiga toxin and related toxins are endocytosed by higher eukaryotic cells. The toxin protein is then transported via the Golgi apparatus to the endoplasmic reticulum (ER) and into the cytosol, where it exerts its toxic effect. This review discusses current understanding of this retrograde transport pathway and how newly developed modified toxins that allow detection and quantification of specific transport steps might prove useful teals in the future.

引用

页码：158 / 162

页数：5

共 57 条

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