Fluorescence diagnosis of endometriosis using 5-aminolevulinic acid

被引:57
作者
Malik, E
Berg, C
Meyhöfer-Malik, A
Buchweitz, O
Moubayed, P
Diedrich, K
机构
[1] Med Univ Lubeck, Dept Obstet & Gynecol, D-23538 Lubeck, Germany
[2] Med Univ Lubeck, Inst Pathol, D-23538 Lubeck, Germany
来源
SURGICAL ENDOSCOPY-ULTRASOUND AND INTERVENTIONAL TECHNIQUES | 2000年 / 14卷 / 05期
关键词
fluorescence diagnosis; endometriosis; 5-aminolevulinic acid; fluorescence; photodynamic diagnosis;
D O I
10.1007/s004640000160
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background: The diagnosis of nonpigmented endometrial lesions by simple laparoscopic visualization is difficult and often inaccurate. We therefore sought to establish a new and more accurate method to visualize these nonpigmented peritoneal changes caused by endometriosis. Methods: A total of 37 patients received 30 mg 5-aminolevulinic acid/kg body weight 10 to 14 hs prior to surgery. Laparoscopy was then performed using a D-Light system (Storz, Tuttlingen, Germany). The findings were evaluated first in the white-light mode; the D-light system was then activated, and all areas of fluorescence were documented. Multiple specimens were obtained by biopsy. Results: The sensitivity of the fluorescence diagnosis in detecting endometriosis in nonpigmented areas and normal-looking peritoneum is 100%, with a specificity of 75%. Diagnosis by simple visualization under white illumination has a sensitivity of only 69% and a specificity of 70%. Occult areas of endometriosis were discovered using fluorescence diagnosis. Conclusions: Our findings suggest that fluorescence diagnosis using 5-aminolevulinic acid is feasible and can improve the diagnosis of endometriosis in nonpigmented and occult endometrial lesions. Fluorescence diagnosis is a promising new tool in the diagnosis of endometriosis.
引用
收藏
页码:452 / 455
页数:4
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