Shifting the limits in wheat research and breeding using a fully annotated reference genome

被引：2210

作者：

Appels, Rudi ^{[1
,35
,37
]}

Eversole, Kellye

Feuillet, Catherine ^{[16
]}

Keller, Beat ^{[40
]}

Rogers, Jane ^{[5
,6
]}

Stein, Nils ^{[3
,4
]}

Pozniak, Curtis J. ^{[10
]}

Choulet, Frederic ^{[6
]}

Distelfeld, Assaf ^{[23
]}

Poland, Jesse ^{[27
]}

Ronen, Gil ^{[11
]}

Sharpe, Andrew G. ^{[42
]}

Pozniak, Curtis ^{[10
]}

Barad, Omer ^{[11
]}

Baruch, Kobi ^{[1
,11
]}

Keeble-Gagnere, Gabriel ^{[1
]}

Mascher, Martin ^{[3
,55
,65
]}

Ben-Zvi, Gil ^{[11
]}

Josselin, Ambre-Aurore ^{[6
]}

Himmelbach, Axel ^{[3
]}

Balfourier, Francois ^{[6
]}

Gutierrez-Gonzalez, Juan ^{[29
]}

Hayden, Matthew ^{[1
]}

Koh, ChuShin ^{[42
]}

Muehlbauer, Gary ^{[29
]}

Pasam, Raj K. ^{[1
]}

Paux, Etienne ^{[6
]}

Rigault, Philippe ^{[38
]}

Tibbits, Josquin ^{[1
]}

Tiwari, Vijay ^{[52
]}

Spannagl, Manuel

Lang, Daniel ^{[8
]}

Gundlach, Heidrun ^{[8
]}

Haberer, Georg ^{[8
]}

Mayer, Klaus F. X. ^{[2
,43
]}

Ormanbekova, Danara ^{[8
]}

Prade, Verena ^{[8
]}

Simkova, Hana ^{[7
]}

Wicker, Thomas ^{[40
]}

Swarbreck, David ^{[48
]}

Rimbert, Helene ^{[6
]}

Felder, Marius ^{[8
]}

Guilhot, Nicolas ^{[6
]}

Kaithakottil, Gemy ^{[48
,58
]}

Keilwagen, Jens ^{[39
]}

Leroy, Philippe ^{[6
]}

Lux, Thomas ^{[8
]}

Twardziok, Sven ^{[8
]}

Venturini, Luca ^{[48
]}

Juhasz, Angela ^{[35
,36
]}

机构：

[1] La Trobe Univ, AgriBio, Ctr AgriBiosci, Dept Econ Dev Jobs Transport & Resources, 5 Ring Rd, Bundoora, Vic 3083, Australia

[2] Eversole Associates, 5207 Wyoming Rd, Bethesda, MD 20816 USA

[3] Leibniz Inst Plant Genet & Crop Plant Res IPK, Genebank, Corrensstr 3, D-06466 Stadt Seeland, Germany

[4] Univ Western Australia UWA, Sch Agr & Environm, 35 Stirling Highway, Crawley, WA 6009, Australia

[5] Int Wheat Genome Sequencing Consortium IWGSC, Little Eversden, 18 High St, Cambridge CB23 1HE, England

[6] Int Wheat Genome Sequencing Consortium IWGSC, Little Eversden, 18 High St, Cambridge CB23 1HE, England

[7] Ctr Reg Hana Biotechnol & Agr Res, Inst Expt Bot, Slechtitelu 31, CZ-78371 Olomouc, Czech Republic

[8] Helmholtz Ctr Munich, Plant Genome & Syst Biol PGSB, Ingolstaedter Landstr 1, D-85764 Neuherberg, Germany

[9] Norwich Res Pk, John Innes Ctr, Crop Genet, Norwich NR4 7UH, Norfolk, England

[10] Univ Saskatchewan, Ctr Crop Dev, Agr Bldg,51 Campus Dr, Saskatoon, SK S7N 5A8, Canada

[11] NRGene Ltd, 5 Golda Meir St, IL-7403648 Ness Ziona, Israel

[12] Univ Paris Saclay, URGI, INRA, F-78026 Versailles, France

[13] Montana State Univ, Cereal Genom Lab, Plant Sci & Plant Pathol, 412 Leon Johnson Hall, Bozeman, MT 59717 USA

[14] Inst Plant Sci Paris Saclay, Dept Biol, Batiment 630,Rue Noetzlin,Plateau Moulon,CS80004, F-91192 Gif Sur Yvette, France

[15] Council Agr Res & Econ CREA, Res Ctr Genom & Bioinformat, Via S Protaso 302, I-29017 Fiorenzuola Darda, Italy

[16] Bayer CropSci, Innovat Ctr, Crop Sci Div, Res & Dev, 3500 Paramount Pkwy, Morrisville, NC 27560 USA

[17] Bayer CropSci, Innovat Ctr, Trait Res, Technol Pk 38, B-9052 Ghent, Belgium

[18] INRA, CNRGV, Chemin Borde Rouge,CS 52627, F-31326 Castanet Tolosan, France

[19] Agr & Agri Food Canada, Swift Current Res & Dev Ctr, Box 1030, Swift Current, SK S9H 3X2, Canada

[20] Natl Res Council Canada, Aquat & Crop Resource Dev, 110 Gymnasium Pl, Saskatoon, SK S7N 0W9, Canada

[21] Russian Acad Sci, Inst Bioengn, Biotechnol Res Ctr, Leninsky Ave 33,Bldg 2, Moscow 119071, Russia

[22] Univ Western Australia, Sch Biol Sci & Inst Agr, Perth, WA 6009, Australia

[23] Tel Aviv Univ, Sch Plant Sci & Food Secur, IL-69978 Ramat Aviv, Israel

[24] Univ Haifa, Inst Evolut, 199 Abba Hushi Ave, IL-3498838 Haifa, Israel

[25] Univ Haifa, Dept Evolutionary & Environm Biol, 199 Abba Hushi Ave, IL-3498838 Haifa, Israel

[26] Univ Malaga, Lenguajes & Ciencias Computac, Campus Teatinos, Malaga 29071, Spain

[27] Kansas State Univ, Plant Pathol, Throckmorton Hall, Manhattan, KS 66506 USA

[28] Univ Haifa, MultiQTL Ltd, IL-3498838 Haifa, Israel

[29] Univ Minnesota, Dept Agron & Plant Genet, 411 Borlaug Hall, St Paul, MN 55108 USA

[30] NARO, Inst Crop Sci, 2-1-2 Kannondai, Tsukuba, Ibaraki 3058518, Japan

[31] Queensland Univ Technol, Earth Environm & Biol Sci, Brisbane, Qld 4001, Australia

[32] CSIC, Inst Agr Sostenible IAS CSIC, Alameda del Obispo S-N, Cordoba 14004, Spain

[33] Univ Calif Davis, Dept Plant Sci, One Shield Ave, Davis, CA 95617 USA

[34] Norwich Res Pk, Sainsbury Lab, Norwich NR4 7UH, Norfolk, England

[35] Murdoch Univ, Sch Vet & Life Sci, Australia China Ctr Wheat Improvement, 90 South St, Murdoch, WA 6150, Australia

[36] MTA Ctr Agr Res, Inst Agr, Appl Genom Dept, 2 Brunszvik St, H-2462 Martonvasar, Hungary

[37] Rothamsted Res, Biointeract & Crop Protect, Harpenden AL5 2JQ, Herts, England

[38] GYDLE, Suite 220,1135 Grande Allee, Ouest, PQ, Canada

[39] Julius Kuhn Inst, Inst Biosafety Plant Biotechnol, Erwin Baur Str 27, D-06484 Quedlinburg, Germany

[40] Univ Zurich, Dept Plant & Microbial Biol, Zollikerstr 107, CH-8008 Zurich, Switzerland

[41] Rothamsted Res, Computat & Analyt Sci, Harpenden AL5 2JQ, Herts, England

[42] Univ Saskatchewan, Global Inst Food Secur, 110 Gymnasium Pl, Saskatoon, SK S7N 4J8, Canada

[43] Tech Univ Munich, Sch Life Sci Weihenstephan, D-85354 Freising Weihenstephan, Germany

[44] Univ Western Australia, ARC Ctr Excellence Plant Energy Biol, Sch Mol Sci, 35 Stirling Highway, Crawley, WA 6009, Australia

[45] Kyoto Univ, Grad Sch Agr, Sakyo Ku, Kitashirakawaoiwake Cho, Kyoto 6068502, Japan

[46] SB RAS, Fed Res Ctr Inst Cytol & Genet, Pr Lavrentyeva 10, Novosibirsk 630090, Russia

[47] Palacky Univ, Ctr Reg Hana Biotechnol & Agr Res, Dept Mol Biol, Slechtitelu 27, CZ-78371 Olomouc, Czech Republic

[48] Core Bioinformat, Earlham Inst, Norwich NR4 7UZ, Norfolk, England

[49] Moscow MV Lomonosov State Univ, Fac Biol, Leninskie Gory 1, Moscow 119991, Russia

[50] Agr & Agri Food Canada, Saskatoon Res & Dev Ctr, 107 Sci Pl, Saskatoon, SK S7N 0X2, Canada

来源：

SCIENCE | 2018年 / 361卷 / 6403期

基金：

英国生物技术与生命科学研究理事会; 澳大利亚研究理事会; 俄罗斯科学基金会; 以色列科学基金会; 美国国家科学基金会;

关键词：

DRAFT GENOME; ADAPTATION; REVEALS; TISSUES; GENES; RICE; KEY;

D O I：

10.1126/science.aar7191

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An annotated reference sequence representing the hexaploid bread wheat genome in 21 pseudomolecules has been analyzed to identify the distribution and genomic context of coding and noncoding elements across the A, B, and D subgenomes. With an estimated coverage of 94% of the genome and containing 107,891 high-confidence gene models, this assembly enabled the discovery of tissue-and developmental stage-related coexpression networks by providing a transcriptome atlas representing major stages of wheat development. Dynamics of complex gene families involved in environmental adaptation and end-use quality were revealed at subgenome resolution and contextualized to known agronomic single-gene or quantitative trait loci. This community resource establishes the foundation for accelerating wheat research and application through improved understanding of wheat biology and genomics-assisted breeding.

引用

页码：661 / +

页数：14

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