Continuous assessment of relative cerebral blood volume in transient ischemia using steady state susceptibility-contrast MRI

The utility of a noninvasive steady state susceptibility-contrast MRI technique for continuous measurement of relative cerebral blood volume (rCBV) during global transient ischemia and subsequent hyperemia in a feline ischemia model is demonstrated, The measurements were obtained during a 10-min period of occlusion and l-h period of reperfusion, Maximal hyperemic responses in gray matter, basal ganglia, and white matter (observed at 7, 7, and 5 min, respectively) were 1.9 +/- 0.5, 1.8 +/- 0.3, and 1.7 +/- 0.6 times greater than baseline CBV (mean +/- SEM), Thirty to forty minutes after onset of reperfusion, CBV returned to normal, Thereafter, it decreased below baseline, nearing the control level by 1 h after onset of reperfusion, Steady state susceptibility-contrast MRI permits continuous, in vivo mapping of alterations in CBV.