Experimental design of a microwave-assisted extraction-derivatization method for the analysis of methylmercury

被引：27

作者：

Abuín, M ^{[1
]}

Carro, AM ^{[1
]}

Lorenzo, RA ^{[1
]}

机构：

[1] Univ Santiago de Compostela, Dept Quim Analyt Nutr & Bromatol, Fac Quim, Santiago De Compostela 15706, Spain

来源：

JOURNAL OF CHROMATOGRAPHY A | 2000年 / 889卷 / 1-2期

关键词：

microwave-assisted extraction; extraction methods; derivatization; GC; factorial design; experimental design; methylmercury; organomercury compounds;

D O I：

10.1016/S0021-9673(00)00210-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A simultaneous microwave-assisted extraction-derivatization procedure was developed and optimized for methylmercury analysis from biological samples. The analyte was derivatized with sodium tetraphenylborate forming a more hydrophobic compound, methylphenylmercury, which was extractable in toluene. The microwave extraction-derivatization procedure was optimized using experimental design, 2(5-1) fractional factorial. This chemometrical approach considers main effects as well as interactions of the influential parameters, indicating that temperature and its interaction with NaBPh4 and acetic acid volumes were the variables that significantly affected methylmercury recoveries. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：185 / 193

页数：9

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