Significance of Resveratrol in Clinical Management of Chronic Diseases

被引：131

作者：

Wahab, Awais ^{[1
]}

Gao, Kuo ^{[1
]}

Jia, Caixia ^{[1
]}

Zhang, Feilong ^{[1
]}

Tian, Guihua ^{[1
,2
]}

Murtaza, Ghulam ^{[1
,3
,4
]}

Chen, Jianxin ^{[1
]}

机构：

[1] Beijing Univ Chinese Med, Sch Preclin Med, Beijing 100029, Peoples R China

[2] Beijing Univ Chinese Med, Dongzhimen Hosp, Beijing 100700, Peoples R China

[3] COMSATS, Inst Informat Technol, Dept Pharm, Abbottabad 22060, Pakistan

[4] Chinese Acad Sci, Inst Automat, Beijing 100029, Peoples R China

来源：

MOLECULES | 2017年 / 22卷 / 08期

基金：

中国国家自然科学基金;

关键词：

pre-clinical studies; clinical studies; absorption; toxicity; diabetes mellitus; obesity; cardiovascular diseases; cancer; aging; BLOOD MONONUCLEAR-CELLS; TRANS-RESVERATROL; PRIMARY PREVENTION; IN-VITRO; GRAPE EXTRACT; DOUBLE-BLIND; SUBSTRATE METABOLISM; INSULIN SENSITIVITY; CALORIC RESTRICTION; SKELETAL-MUSCLE;

D O I：

10.3390/molecules22081329

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Resveratrol could be beneficial to health and provides protection against a wide array of pathologies and age-associated problems, as evident from preclinical studies. However, a comparison of animal and human studies reveals that this dietary polyphenol cannot protect against metabolic diseases and their associated complications. The clinical outcomes are affected by many factors such as sample size. This article not only presents a comprehensive review of the current advances concerning the dose, the extent of absorption, interaction and toxicity of resveratrol in human studies, but also describes its therapeutic effects against several chronic diseases such as diabetes mellitus, obesity, cardiovascular diseases, cancer and aging and the related diseases.

引用

页数：19

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