Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5

被引：289

作者：

Lederman, MM

Veazey, RS

Offord, R

Mosier, DE

Dufour, J

Mefford, M

Piatak, M

Lifson, JD

Salkowitz, JR

Rodriguez, B

Blauvelt, A

Hartley, O

机构：

[1] Case Western Reserve Univ, Univ Hosp, Dept Med, Cleveland, OH 44106 USA

[2] Tulane Natl Primate Res Ctr, Covington, LA 70433 USA

[3] Univ Geneva, Fac Med, Dept Struct Biol & Bioinformat, CH-1211 Geneva 4, Switzerland

[4] Scripps Res Inst, La Jolla, CA 92037 USA

[5] NCI, AIDS Vaccine Program, SAIC Frederick Inc, Frederick, MD 21702 USA

[6] NCI, Dermatol Branch, Bethesda, MD 20892 USA

来源：

SCIENCE | 2004年 / 306卷 / 5695期

关键词：

D O I：

10.1126/science.1099288

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Topical agents, such as microbicides, that can protect against human immunodeficiency virus (HIV) transmission are urgently needed. Using a chimeric simian/human immunodeficiency virus (SHIV SF162), which is tropic for the chemokine receptor CCR5, we report that topical application of high doses of PSC-RANTES, an amino terminus-modified analog of the chemokine RANTES, provided potent protection against vaginal challenge in rhesus macaques. These experimental findings have potentially important implications for understanding vaginal transmission of HIV and the design of strategies for its prevention.

引用

页码：485 / 487

页数：3

共 33 条

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