Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays

被引：304

作者：

Matsuzaki, H ^{[1
]}

Dong, SL ^{[1
]}

Loi, H ^{[1
]}

Di, XJ ^{[1
]}

Liu, GY ^{[1
]}

Hubbell, E ^{[1
]}

Law, J ^{[1
]}

Berntsen, T ^{[1
]}

Chadha, M ^{[1
]}

Hui, H ^{[1
]}

Yang, GR ^{[1
]}

Kennedy, GC ^{[1
]}

Webster, TA ^{[1
]}

Cawley, S ^{[1
]}

Walsh, PS ^{[1
]}

Jones, KW ^{[1
]}

Fodor, SPA ^{[1
]}

Mei, R ^{[1
]}

机构：

[1] Affymetrix Inc, Santa Clara, CA 95051 USA

来源：

NATURE METHODS | 2004年 / 1卷 / 02期

关键词：

D O I：

10.1038/nmeth718

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a genotyping method for simultaneously scoring 116,204 SNPs using oligonucleotide arrays. At call rates >99%, reproducibility is >99.97% and accuracy, as measured by inheritance in trios and concordance with the HapMap Project, is >99.7%. Average intermarker distance is 23.6 kb, and 92% of the genome is within 100 kb of a SNP marker. Average heterozygosity is 0.30, with 105,511 SNPs having minor allele frequencies >5%.

引用

页码：109 / 111

页数：3

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