Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease

被引：406

作者：

Marcus, DL ^{[1
]}

Thomas, C ^{[1
]}

Rodriguez, C ^{[1
]}

Simberkoff, K ^{[1
]}

Tsai, JS ^{[1
]}

Strafaci, JA ^{[1
]}

Freedman, ML ^{[1
]}

机构：

[1] NYU, Med Ctr, Div Geriatr, New York, NY 10016 USA

来源：

EXPERIMENTAL NEUROLOGY | 1998年 / 150卷 / 01期

基金：

美国国家卫生研究院;

关键词：

peroxidation; antioxidation; Alzheimer's disease; superoxide dismutase;

D O I：

10.1006/exnr.1997.6750

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The overall peroxidation activity in brain tissue by region from patients with Alzheimer's disease (AD) and age-matched controls was determined employing the thiobarbituric acid-reactive substances (TEARS) assay, a measure of lipid peroxidation, followed by a determination the activities of the antioxidant enzymes Cu/Zn superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT), in the frontal, temporal, and cerebellar cortex of 10 AD and 9 control brains. The level of TEARS was elevated in all regions, with particular statistical significance in the temporal cortex when compared to age-matched controls. SOD activity was significantly decreased in AD frontal and AD temporal cortex, while catalase activity was significantly decreased in AD temporal cortex. There was no significant difference in GSH-Px activity found in any of the regions examined. This study supports the theory that in ED the brain is affected by increased oxidative stress which, when combined with a decrease in SOD activity, produces oxidative alterations, seen most significantly in temporal cortex in AD, where the pathophysiologic changes are most severe. (C) 1998 Academic Press.

引用

页码：40 / 44

页数：5

共 31 条

[1]

AEBI H, 1984, METHOD ENZYMOL, V105, P121

[2]

ANDORN AC, 1990, NEUROBIOL AGING, V11, P316

[3] NEUROFIBRILLARY TANGLES BUT NOT SENILE PLAQUES PARALLEL DURATION AND SEVERITY OF ALZHEIMERS-DISEASE [J].