A pilot study of combination therapy with indinavir, stauvidine (d4T), and didanosine (ddI) in children infected with the human immunodeficiency virus

被引：45

作者：

Kline, MW

Fletcher, CV

Harris, AT

Evans, KD

Brundage, RC

Remmel, RP

Calles, NR

Kirkpatrick, SB

Simon, C

机构：

[1] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[2] Texas Childrens Hosp, Houston, TX 77030 USA

[3] Univ Minnesota, Coll Pharm, Minneapolis, MN 55455 USA

来源：

JOURNAL OF PEDIATRICS | 1998年 / 132卷 / 03期

关键词：

D O I：

10.1016/S0022-3476(98)70039-3

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Twelve children infected with the human immunodeficiency virus were treated orally with indinavir, stavudine, plus didanosine for 12 to 48 weeks. Therapy was limited in some cases by nonadherence, intolerance, toxicity, and virologic failure. Marked increases in CD4+ lymphocyte counts and decreases in plasma human immunodeficiency virus RNA concentrations suggest that the regimen has patent antiviral activity.

引用

页码：543 / 546

页数：4

共 8 条

[1] [Anonymous], 1994, MMWR Recomm Rep, V43, P1
[2] Gibaldi M. P., 1982, PHARMACOKINETICS
[3] *MERCK CO INC, 1996, CRIXIVAN INDINAVIR S
[4] Ordered accumulation of mutations in HIV protease confers resistance to ritonavir
Molla, A
Korneyeva, M
Gao, Q
Vasavanonda, S
Schipper, PJ
Mo, HM
Markowitz, M
Chernyavskiy, T
Niu, P
Lyons, N
Hsu, A
Granneman, GR
Ho, DD
Boucher, CAB
Leonard, JM
Norbeck, DW
Kempf, DJ
[J]. NATURE MEDICINE, 1996, 2 (07) : 760 - 766
[5] Virologic markers of human immunodeficiency virus type 1 in cerebrospinal fluid of infected children
Pratt, RD
Nichols, S
McKinney, N
Kwok, S
Dankner, WM
Spector, SA
[J]. JOURNAL OF INFECTIOUS DISEASES, 1996, 174 (02) : 288 - 293
[6] The effect of high-dose saquinavir on viral load and CD4(+) T-cell counts in HIV-infected patients
Schapiro, JM
Winters, MA
Stewart, F
Efron, B
Norris, J
Kozal, MJ
Merigan, TC
[J]. ANNALS OF INTERNAL MEDICINE, 1996, 124 (12) : 1039 - 1050
[7] A 24-week open-label phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir)
Stein, DS
Fish, DG
Bilello, JA
Preston, SL
Martineau, GL
Drusano, GL
[J]. AIDS, 1996, 10 (05) : 485 - 492
[8] Indinavir nephropathy
Tashima, KT
Horowitz, JD
Rosen, S
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (02) : 138 - 140

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