Dopamine receptor mRNAs in the rat lymphocytes

被引：35

作者：

Caronti, B ^{[1
]}

Calderaro, C ^{[1
]}

Passarelli, F ^{[1
]}

Palladini, G ^{[1
]}

Pontieri, FE ^{[1
]}

机构：

[1] Univ La Sapienza, Dept Neurosci, I-00185 Rome, Italy

来源：

LIFE SCIENCES | 1998年 / 62卷 / 21期

关键词：

dopamine receptor; lymphocytes; mRNA;

D O I：

10.1016/S0024-3205(98)00160-X

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

It has been suggested that dopamine might play a role in the regulation of the immune system. In this study, reverse transcriptase-polymerase chain reaction (RT-PCR) was used to investigate the expression of mRNA for the different subtypes of dopamine receptors in the rat lymphocytes. D1, D3 and D5 receptor mRNAs were identified. These results provide further evidence for the interaction of dopamine systems and the immune system, and suggest to further investigate whether the immunosuppressive actions of dopamine and dopaminergic drugs might depend on a direct interaction with dopamine receptors on the lymphocyte membrane. Moreover, they suggest the suitability of this animal species to further investigate the correlation between changes in the expression of central and peripheral dopamine receptors produced by manipulations of the dopamine systems.

引用

页码：1919 / 1925

页数：7

共 24 条

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