The crucial role of vascular permeability factor/vascular endothelial growth factor in angiogenesis: a historical review

被引：146

作者：

Ribatti, D ^{[1
]}

机构：

[1] Univ Bari, Dept Human Anat & Histol, Sch Med, I-70124 Bari, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2005年 / 128卷 / 03期

关键词：

angiogenesis; history of medicine; vascular permeability factor; vascular endothelial growth factor;

D O I：

10.1111/j.1365-2141.2004.05291.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Angiogenesis is a biological process by which new capillaries are formed and it occurs in many physiological and pathological conditions. It is controlled by the net balance between molecules that have positive and negative regulatory activity and this concept had led to the notion of the 'angiogenic switch', depending on an increased production of one or more of the positive regulators of angiogenesis. Numerous inducers of angiogenesis have been identified and this review offers a historical account of the relevant literature concerning the discovery of one of the best characterized angiogenic factors, namely vascular endothelial growth factor (VEGF)/vascular permeability factor. Moreover, different strategies, designed to stimulate and to inhibit VEGF production in the context of several potential therapeutical implications, are discussed.

引用

页码：303 / 309

页数：7

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