Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability

被引：21

作者：

Tong, YS ^{[1
]}

Lin, NH ^{[1
]}

Wang, L ^{[1
]}

Hasvold, L ^{[1
]}

Wang, WB ^{[1
]}

Leonard, N ^{[1
]}

Li, TM ^{[1
]}

Li, Q ^{[1
]}

Cohen, J ^{[1
]}

Gu, WZ ^{[1
]}

Zhang, HY ^{[1
]}

Stoll, V ^{[1
]}

Bauch, J ^{[1
]}

Marsh, K ^{[1
]}

Rosenberg, SH ^{[1
]}

Sham, HL ^{[1
]}

机构：

[1] Abbott Labs, Global Pharmaceut R&D, Abbott Pk, IL 60064 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(03)00195-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A pyridyl moiety was introduced into a previously developed series of farnesyltransferase inhibitors containing imidazole and cyanophenyl (such as 4), resulting in potent inhibitors with improved pharmacokinetics. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1571 / 1574

页数：4

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