Efficacy of acute administration of nicotine gum in relief of cue-provoked cigarette craving

被引:113
作者
Shiffman, S
Shadel, WG
Niaura, R
Khayrallah, MA
Jorenby, DE
Ryan, CF
Ferguson, CL
机构
[1] Pinney Associates, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Pittsburgh, PA 15213 USA
[3] Howard Univ, Coll Med, Dept Pharmacol, Washington, DC 20060 USA
[4] Univ Wisconsin, Sch Med, Dept Med, Madison, WI 53711 USA
[5] Univ Wisconsin, Sch Med, Ctr Tobacco Res & Intervent, Madison, WI 53711 USA
[6] Cytran Inc, Kirkland, WA 98033 USA
[7] Brown Univ, Sch Med, Ctr Behav Med, Providence, RI 02903 USA
[8] Brown Univ, Sch Med, Ctr Prevent Med, Providence, RI 02903 USA
[9] Miriam Hosp, Providence, RI 02903 USA
关键词
nicotine replacement; smoking cessation; craving; cue reactivity; nicotine gum;
D O I
10.1007/s00213-002-1338-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Rationale: Acute cravings, often provoked by exposure to smoking cues, appear to be important triggers for smoking relapse. Relief of acute craving may therefore be an important step in preventing relapse. Objectives: This study was undertaken to assess the effectiveness of nicotine gum in relieving acute craving. Methods: A multi-center, randomized, placebo-controlled study was conducted with smokers (n=296) who quit by using either active or inactive gum for 3 days. On their third day of abstinence, smokers participated in a laboratory session in which they were exposed to a provocative smoking cue, chewed active or inactive gum, and then rated their craving at 5-min intervals for 35 min. Results: Craving initially decreased in both groups. After 15 min, however, the smokers using active nicotine gum experienced significantly greater craving reductions. Conclusions: These results suggest that nicotine gum can effectively reduce acute craving following exposure to smoking cues.
引用
收藏
页码:343 / 350
页数:8
相关论文
共 46 条
[1]   REACTIVITY TO SMOKING CUES AND RELAPSE - 2 STUDIES OF DISCRIMINANT VALIDITY [J].
ABRAMS, DB ;
MONTI, PM ;
CAREY, KB ;
PINTO, RP ;
JACOBUS, SI .
BEHAVIOUR RESEARCH AND THERAPY, 1988, 26 (03) :225-233
[2]   A PSYCHOPHYSICAL TASK TO QUANTIFY SMOKING CESSATION-INDUCED IRRITABILITY - THE REACTIVE IRRITABILITY SCALE (RIS) [J].
ACRI, JB ;
GRUNBERG, NE .
ADDICTIVE BEHAVIORS, 1992, 17 (06) :587-601
[3]  
*AG HLTH CAR POL R, 2000, YOU CAN QUIT SMOK CO
[4]  
American Psychiatric Association, 1995, DIAGN STAT MAN MENT
[5]  
BAKER TB, 1987, NEBR S MOT ALC US AB, P257
[6]   NICOTINE ABSORPTION AND CARDIOVASCULAR EFFECTS WITH SMOKELESS TOBACCO USE - COMPARISON WITH CIGARETTES AND NICOTINE GUM [J].
BENOWITZ, NL ;
PORCHET, H ;
SHEINER, L ;
JACOB, P .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1988, 44 (01) :23-28
[7]   THE INFLUENCE OF SITUATION AND COPING ON RELAPSE CRISIS OUTCOMES AFTER SMOKING CESSATION [J].
BLISS, RE ;
GARVEY, AJ ;
HEINOLD, JW ;
HITCHCOCK, JL .
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY, 1989, 57 (03) :443-449
[8]   Nicotine nasal spray with nicotine patch for smoking cessation: Randomised trial with six year follow up [J].
Blondal, T ;
Gudmundsson, LJ ;
Olafsdottir, I ;
Gustavsson, G ;
Westin, A .
BRITISH MEDICAL JOURNAL, 1999, 318 (7179) :285-288
[9]   Cigarette smoking and chewing gum: Response to a laboratory-induced stressor [J].
Britt, DM ;
Cohen, LM ;
Collins, FL ;
Cohen, ML .
HEALTH PSYCHOLOGY, 2001, 20 (05) :361-368
[10]   Meta-analysis of cue-reactivity in addiction research [J].
Carter, BL ;
Tiffany, ST .
ADDICTION, 1999, 94 (03) :327-340