Potential for early involvement of CYP isoforms in aspects of human cadmium toxicity

被引:30
作者
Baker, JR
Satarug, S
Edwards, RJ
Moore, MR
Williams, DJ
Reilly, PEB
机构
[1] Univ Queensland, Natl Res Ctr Environm Toxicol, Brisbane, Qld 4108, Australia
[2] Imperial Coll Sch Med, Clin Pharmacol Sect, London, England
[3] Queensland Dept Hlth, John Tonge Ctr Forens Pathol, Queensland Hlth Sci Serv, Brisbane, Qld, Australia
[4] Univ Queensland, Dept Biochem, Brisbane, Qld 4072, Australia
关键词
CYP4A11; hypertension; cadmium toxicity;
D O I
10.1016/S0378-4274(02)00382-X
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
This paper investigates the possible link between non-workplace cadmium (Cd) exposure, cytochrome P450 expression and hypertension. We present results of our investigation into the relationships between liver and kidney Cd burdens and the abundance of the CYP isoform 4A11. Our data show associations between non-workplace Cd exposure and changes in the abundance of hepatic and renal cortical CYP4A11. In liver the levels of immunochemically detectable CYP4A11 were positively correlated with tissue Cd content while in contrast CYP4A11 abundance was inversely correlated with kidney Cd burden. These differences are most likely related to the different Cd burden of the tissues. These observations suggest the potential for involvement of Cd as a mediator of CYP4A11 expression in kidney cortex and indicate that elevations in kidney Cd content may be involved in hypertension via alteration of the expression of this particular isoform. Potential mechanisms by which Cd may alter CYP4A11 expression are discussed briefly. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:85 / 93
页数:9
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