Some derivatives of 5α-ketosteroid hydrazones:: Synthesis from tigogenin and antituberculosis activity

被引：40

作者：

Merlani, MI ^{[1
]}

Kemertelidze, EP

Papadopoulos, K

Men'shova, NI

机构：

[1] Georgian Acad Sci, Kutateladze Inst Pharmacochem, GE-0159 Tbilisi, Georgia

[2] Natl Res Ctr Demokritos, Inst Chem Phys, Athens, Greece

[3] All Russia Res Inst Pharmaceut Chem, Ctr Drug Chem, Moscow, Russia

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2004年 / 30卷 / 05期

关键词：

antimycobacterial activity; isonicotinoylhydrazones; 5; alpha-ketosteroids; synthesis;

D O I：

10.1023/B:RUBI.0000043795.25417.60

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Isonicotinoylhydrazones and thiosemicarbazones of some 5alpha-ketosteroids were synthesized from tigogenin, and their structures were confirmed by NMR and IR spectroscopy and mass spectrometry. Their antimycobacterial activities were studied and it was shown that some of the synthesized isonicotinoylhydrazones exhibit a high antituberculosis activity.

引用

页码：497 / 501

页数：5

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