Long-Evans Cinnamon (LEC) rats, an inbred mutant strain which accumulates copper due to an aberrant copper-transporting ATPase gene, develop acute hepatitis, chronic liver injury and liver tumors as a result of copper-induced oxidative stress, lipid peroxidation and DNA damage. Curcumin, an antioxidant and anti-inflammatory agent, has shown anticancer properties in many rodent models. We investigated the modulating role of curcumin in liver and kidney carcinogenesis in LEC rats. Two groups of 4-week-old LEC rats (n = 60 each) were fed either a standard diet (control) or received 0.5% curcumin in the diet for life. In untreated LEC rats, the rate of acute liver failure, the incidence of liver tumors and of kidney tumors were 32, 100 and 10% respectively, which was not altered by curcumin treatment. However, curcumin reduced tumor incidence at other organ sites (15% versus 0%; P = 0.025) and suppressed formation of metastases (18% versus 0%; P = 0.01). Median survival time was decreased from 88.7 to 78.1 weeks in curcumin-treated rats (P = 0.002). The lack of chemoprevention of liver and kidney tumors in LEC rats by curcumin may be caused by enhanced toxicity and oxidative stress due to excess copper. We conclude that curcumin should be contra-indicated for patients suffering from inherited and acquired metal storage diseases that include patients with hepatitis C virus infection. (C) 2002 Elsevier Science B.V. All rights reserved.
机构:
DKFZ, German Canc Res Ctr, Div Toxicol & Canc Risk Factors, D-69120 Heidelberg, GermanyDKFZ, German Canc Res Ctr, Div Toxicol & Canc Risk Factors, D-69120 Heidelberg, Germany
Bartsch, H
;
Nair, J
论文数: 0引用数: 0
h-index: 0
机构:
DKFZ, German Canc Res Ctr, Div Toxicol & Canc Risk Factors, D-69120 Heidelberg, GermanyDKFZ, German Canc Res Ctr, Div Toxicol & Canc Risk Factors, D-69120 Heidelberg, Germany
机构:
INT AGCY RES CANC, ENDOGENOUS CANC RISK FACTORS UNIT, F-69372 LYON 08, FRANCEINT AGCY RES CANC, ENDOGENOUS CANC RISK FACTORS UNIT, F-69372 LYON 08, FRANCE
BROUET, I
;
OHSHIMA, H
论文数: 0引用数: 0
h-index: 0
机构:
INT AGCY RES CANC, ENDOGENOUS CANC RISK FACTORS UNIT, F-69372 LYON 08, FRANCEINT AGCY RES CANC, ENDOGENOUS CANC RISK FACTORS UNIT, F-69372 LYON 08, FRANCE
机构:
NATL INST NUTR,FOOD & DRUG TOXICOL RES CTR,HYDERABAD 500007,ANDHRA PRADESH,INDIANATL INST NUTR,FOOD & DRUG TOXICOL RES CTR,HYDERABAD 500007,ANDHRA PRADESH,INDIA
GOUD, VK
;
POLASA, K
论文数: 0引用数: 0
h-index: 0
机构:
NATL INST NUTR,FOOD & DRUG TOXICOL RES CTR,HYDERABAD 500007,ANDHRA PRADESH,INDIANATL INST NUTR,FOOD & DRUG TOXICOL RES CTR,HYDERABAD 500007,ANDHRA PRADESH,INDIA
POLASA, K
;
KRISHNASWAMY, K
论文数: 0引用数: 0
h-index: 0
机构:
NATL INST NUTR,FOOD & DRUG TOXICOL RES CTR,HYDERABAD 500007,ANDHRA PRADESH,INDIANATL INST NUTR,FOOD & DRUG TOXICOL RES CTR,HYDERABAD 500007,ANDHRA PRADESH,INDIA
机构:
Washington Univ, Sch Med, Edward Mallinckrodt Dept Pediat, St Louis, MO 63110 USAWashington Univ, Sch Med, Edward Mallinckrodt Dept Pediat, St Louis, MO 63110 USA
Hamza, I
;
Schaefer, M
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Edward Mallinckrodt Dept Pediat, St Louis, MO 63110 USAWashington Univ, Sch Med, Edward Mallinckrodt Dept Pediat, St Louis, MO 63110 USA
Schaefer, M
;
Klomp, LWJ
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Edward Mallinckrodt Dept Pediat, St Louis, MO 63110 USAWashington Univ, Sch Med, Edward Mallinckrodt Dept Pediat, St Louis, MO 63110 USA
Klomp, LWJ
;
Gitlin, JD
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Edward Mallinckrodt Dept Pediat, St Louis, MO 63110 USAWashington Univ, Sch Med, Edward Mallinckrodt Dept Pediat, St Louis, MO 63110 USA
机构:
DKFZ, German Canc Res Ctr, Div Toxicol & Canc Risk Factors, D-69120 Heidelberg, GermanyDKFZ, German Canc Res Ctr, Div Toxicol & Canc Risk Factors, D-69120 Heidelberg, Germany
Bartsch, H
;
Nair, J
论文数: 0引用数: 0
h-index: 0
机构:
DKFZ, German Canc Res Ctr, Div Toxicol & Canc Risk Factors, D-69120 Heidelberg, GermanyDKFZ, German Canc Res Ctr, Div Toxicol & Canc Risk Factors, D-69120 Heidelberg, Germany
机构:
INT AGCY RES CANC, ENDOGENOUS CANC RISK FACTORS UNIT, F-69372 LYON 08, FRANCEINT AGCY RES CANC, ENDOGENOUS CANC RISK FACTORS UNIT, F-69372 LYON 08, FRANCE
BROUET, I
;
OHSHIMA, H
论文数: 0引用数: 0
h-index: 0
机构:
INT AGCY RES CANC, ENDOGENOUS CANC RISK FACTORS UNIT, F-69372 LYON 08, FRANCEINT AGCY RES CANC, ENDOGENOUS CANC RISK FACTORS UNIT, F-69372 LYON 08, FRANCE
机构:
NATL INST NUTR,FOOD & DRUG TOXICOL RES CTR,HYDERABAD 500007,ANDHRA PRADESH,INDIANATL INST NUTR,FOOD & DRUG TOXICOL RES CTR,HYDERABAD 500007,ANDHRA PRADESH,INDIA
GOUD, VK
;
POLASA, K
论文数: 0引用数: 0
h-index: 0
机构:
NATL INST NUTR,FOOD & DRUG TOXICOL RES CTR,HYDERABAD 500007,ANDHRA PRADESH,INDIANATL INST NUTR,FOOD & DRUG TOXICOL RES CTR,HYDERABAD 500007,ANDHRA PRADESH,INDIA
POLASA, K
;
KRISHNASWAMY, K
论文数: 0引用数: 0
h-index: 0
机构:
NATL INST NUTR,FOOD & DRUG TOXICOL RES CTR,HYDERABAD 500007,ANDHRA PRADESH,INDIANATL INST NUTR,FOOD & DRUG TOXICOL RES CTR,HYDERABAD 500007,ANDHRA PRADESH,INDIA
机构:
Washington Univ, Sch Med, Edward Mallinckrodt Dept Pediat, St Louis, MO 63110 USAWashington Univ, Sch Med, Edward Mallinckrodt Dept Pediat, St Louis, MO 63110 USA
Hamza, I
;
Schaefer, M
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Edward Mallinckrodt Dept Pediat, St Louis, MO 63110 USAWashington Univ, Sch Med, Edward Mallinckrodt Dept Pediat, St Louis, MO 63110 USA
Schaefer, M
;
Klomp, LWJ
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Edward Mallinckrodt Dept Pediat, St Louis, MO 63110 USAWashington Univ, Sch Med, Edward Mallinckrodt Dept Pediat, St Louis, MO 63110 USA
Klomp, LWJ
;
Gitlin, JD
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Edward Mallinckrodt Dept Pediat, St Louis, MO 63110 USAWashington Univ, Sch Med, Edward Mallinckrodt Dept Pediat, St Louis, MO 63110 USA