Positron emission tomography in female patients with Borderline personality disorder

被引：105

作者：

Juengling, FD

Schmahl, C

Hesslinger, B

Ebert, D

Bremner, JD

Gostomzyk, J

Bohus, M

Lieb, K

机构：

[1] Univ Freiburg, Sch Med, Dept Psychiat & Psychotherapy, D-79104 Freiburg, Germany

[2] Univ Freiburg, Sch Med, PET Grp, Dept Nucl Med, D-79106 Freiburg, Germany

[3] Atlanta VAMC, Decatur, GA USA

[4] Emory Univ, Sch Med, Dept Psychiat, Atlanta, GA 30322 USA

[5] Emory Univ, Sch Med, Dept Behav Sci, Atlanta, GA 30322 USA

[6] Emory Univ, Sch Med, Dept Radiol, Atlanta, GA 30322 USA

[7] Emory Univ, Sch Med, Ctr Positron Emiss Tomog, Atlanta, GA 30322 USA

[8] Univ Hosp Ulm, Dept Psychiat, D-89075 Ulm, Germany

来源：

JOURNAL OF PSYCHIATRIC RESEARCH | 2003年 / 37卷 / 02期

关键词：

Borderline personality disorder; positron emission tomography; limbic system; prefrontal cortex; POSTTRAUMATIC-STRESS-DISORDER; OBSESSIVE-COMPULSIVE DISORDER; HIPPOCAMPAL VOLUME; SEXUAL ABUSE; FDG-PET; GLUCOSE-METABOLISM; PAIN; VALIDATION; INTERVIEW; AMYGDALA;

D O I：

10.1016/S0022-3956(02)00084-5

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The pathology of Borderline personality disorder (BPD) is poorly understood and its biological basis remains largely unknown. One functional brain imaging study using [F-18]Deoxyglucose-PET previously reported frontal and prefrontal hypometabolism. We studied brain metabolism at baseline in 12 medication-free female patients with BPD without current substance abuse or depression and 12 healthy female controls by [F-18]Deoxyglucose-PET and statistical parametric mapping. We found significant frontal and prefrontal hypermetabolism in patients with BPD relative to controls as well as significant hypometabolism in the hippocampus and cuneus. This study demonstrated limbic and prefrontal dysfunction under resting conditions in patients with BPD by FDG-PET. Dysfunction in this network of brain regions, which has been implicated in the regulation of emotion, may underlie symptoms of BPD. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：109 / 115

页数：7

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