Anthropometric Measures, Body Mass Index, and Pancreatic Cancer A Pooled Analysis From the Pancreatic Cancer Cohort Consortium (PanScan)

被引：270

作者：

Arslan, Alan A. ^{[1
,2
,3
]}

Helzlsouer, Kathy J. ^{[4
]}

Kooperberg, Charles ^{[5
]}

Shu, Xiao-Ou ^{[6
,7
]}

Steplowski, Emily ^{[8
]}

Bueno-de-Mesquita, H. Bas ^{[9
,10
]}

Fuchs, Charles S. ^{[11
,12
]}

Gross, Myron D. ^{[18
]}

Jacobs, Eric J. ^{[19
]}

LaCroix, Andrea Z. ^{[5
]}

Petersen, Gloria M. ^{[20
]}

Stolzenberg-Solomon, Rachael Z. ^{[22
]}

Zheng, Wei ^{[6
,7
]}

Albanes, Demetrius ^{[22
]}

Amundadottir, Laufey ^{[22
,23
]}

Bamlet, William R. ^{[20
]}

Barricarte, Aurelio ^{[25
,26
]}

Bingham, Sheila A. ^{[27
]}

Boeing, Heiner ^{[28
]}

Boutron-Ruault, Marie-Christine ^{[29
,30
]}

Buring, Julie E. ^{[17
]}

Chanock, Stephen J. ^{[22
,23
]}

Clipp, Sandra ^{[31
]}

Gaziano, J. Michael ^{[13
,14
,15
,32
]}

Giovannucci, Edward L. ^{[12
,33
,34
]}

Hankinson, Susan E. ^{[12
,34
]}

Hartge, Patricia ^{[22
]}

Hoover, Robert N. ^{[22
]}

Hunter, David J. ^{[12
,34
]}

Hutchinson, Amy ^{[22
,36
]}

Jacobs, Kevin B. ^{[22
,36
,37
]}

Kraft, Peter ^{[34
,35
]}

Lynch, Shannon M. ^{[24
]}

Manjer, Jonas ^{[38
]}

Manson, JoAnn E. ^{[16
,34
]}

McTiernan, Anne ^{[5
]}

McWilliams, Robert R. ^{[21
]}

Mendelsohn, Julie B. ^{[22
]}

Michaud, Dominique S. ^{[39
]}

Palli, Domenico ^{[40
]}

Rohan, Thomas E. ^{[41
]}

Slimani, Nadia ^{[42
]}

Thomas, Gilles ^{[22
]}

Tjonneland, Anne ^{[43
]}

Tobias, Geoffrey S. ^{[22
]}

Trichopoulos, Ditnitrios ^{[34
,44
]}

Virtamo, Jarmo ^{[45
]}

Wolpin, Brian M. ^{[11
,12
]}

Yu, Kai ^{[22
]}

Zeleniuch-Jacquotte, Anne ^{[2
,3
]}

机构：

[1] NYU, Dept Obstet & Gynecol, Sch Med, New York, NY 10016 USA

[2] NYU, Dept Environm Med, Sch Med, New York, NY 10016 USA

[3] NYU, Inst Canc, New York, NY 10016 USA

[4] Mercy Med Ctr, Prevent & Res Ctr, Baltimore, MD USA

[5] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA

[6] Vanderbilt Univ, Dept Med, Div Epidemiol, Vanderbilt Epidemiol Ctr, Nashville, TN USA

[7] Vanderbilt Univ, Vanderbilt Ingram Canc Ctr, Nashville, TN USA

[8] Informat Management Serv Inc, Silver Spring, MD USA

[9] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[10] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[11] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[12] Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA

[13] Brigham & Womens Hosp, Div Prevent Med, Phys Hlth Study, Boston, MA 02115 USA

[14] Brigham & Womens Hosp, Div Aging, Phys Hlth Study, Boston, MA 02115 USA

[15] Brigham & Womens Hosp, Div Cardiovasc Med, Phys Hlth Study, Boston, MA 02115 USA

[16] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[17] Harvard Univ, Sch Med, Dept Ambulatory Care & Prevent, Boston, MA USA

[18] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA

[19] Amer Canc Soc, Dept Epidemiol, Atlanta, GA 30329 USA

[20] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

[21] Mayo Clin, Dept Oncol, Coll Med, Rochester, MN USA

[22] NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA

[23] NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA

[24] NCI, Div Canc Control & Populat Sci, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA

[25] CIBER Epidemiol & Salud Publ, Barcelona, Spain

[26] Publ Hlth Inst Navarra, Pamplona, Spain

[27] Univ Cambridge, MRC Ctr Nutr & Canc, Cambridge, England

[28] German Inst Human Nutr, Potsdam, Nuthetal, Germany

[29] INSERM, Villejuif, France

[30] Inst Gustave Roussy, Villejuif, France

[31] George W Comstock Ctr Publ Hlth Res & Prevent, Hagerstown, MD USA

[32] Harvard Univ, Sch Publ Hlth, Massachusetts Vet Epidemiol Res & Informat Ctr, Vet Affairs Boston Healthcare Syst, Boston, MA 02115 USA

[33] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[34] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[35] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[36] NCI, Core Genotyping Facil, Adv Technol Program, SAIC Frederick Inc, Frederick, MD 21701 USA

[37] Bioinformed Consulting Serv LLC, Gaithersburg, MD USA

[38] Malmo Univ Hosp, Dept Surg, Malmo, Sweden

[39] Univ London Imperial Coll Sci Technol & Med, Div Epidemiol Publ Hlth & Primary Care, London, England

[40] Canc Res & Prevent Inst, Mol & Nutr Epidemiol Unit, Florence, Italy

[41] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA

[42] Int Agcy Res Canc, F-69372 Lyon, France

[43] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[44] Univ Athens, Sch Med, Dept Hyg & Epidemiol, Athens, Greece

[45] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland

来源：

ARCHIVES OF INTERNAL MEDICINE | 2010年 / 170卷 / 09期

基金：

美国国家卫生研究院;

关键词：

LIFE-STYLE FACTORS; PHYSICAL-ACTIVITY; NUTRITIONAL FACTORS; RISK-FACTORS; OBESITY; INSULIN; HEALTH; DESIGN; OVERWEIGHT; ADIPOSITY;

D O I：

10.1001/archinternmed.2010.63

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Obesity has been proposed as a risk factor for pancreatic cancer. Methods: Pooled data were analyzed from the National Cancer Institute Pancreatic Cancer Cohort Consortium (PanScan) to study the association, between prediagnostic anthropometric measures and risk of pancreatic cancer. PanScan applied a nested case-control study design and included 2170 cases and 2209 control subjects. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression for cohort-specific quartiles of body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]), weight, height, waist circumference, and waist to hip ratio as well as conventional BMI categories (underweight, <18.5; normal weight, 18.5-24.9; overweight, 25.0-29.9; obese, 30.0-34.9; and severely obese, >= 35.0). Models were adjusted for potential confounders. Results: In all of the participants, a positive association between increasing BMI and risk of pancreatic cancer was observed (adjusted OR for the highest vs lowest BMI guartile, 1.33; 95% Cl, 1.12-1.58; P-trend<.001). In men, the adjusted OR for pancreatic cancer for the highest vs lowest quartile of BMI was 1.33 (95% Cl, 1.04-1.69; P-trend<.03), and in women it was 1.34 (95% Cl, 1.05-1.70; P-trend=.01). Increased waist to hip ratio was associated with increased risk of pancreatic cancer in women (adjusted OR for the highest vs lowest quartile, 1.87; 95% Cl, 1.31-2.69; P-trend=.003) but less so in men. Conclusions: These findings provide strong support for a positive association between BMI and pancreatic cancer risk. In addition, centralized fat distribution may increase pancreatic cancer risk, especially in women. Arch Intern Med. 2010;170(9):791 -802

引用

页码：791 / 802

页数：12

共 57 条

[1] Anderson G, 1998, CONTROL CLIN TRIALS, V19, P61
[2] [Anonymous], 1994, Ann Epidemiol, V4, P1
[3] [Anonymous], 1992, J MYOCARDIAL ISCHAEM
[4] [Anonymous], 2009, CANC FACTS FIG 2009
[5] Obesity and overweight in relation to organ-specific cancer mortality in London (UK): findings from the original Whitehall study
Batty, GD
Shipley, MJ
Jarrett, RJ
Breeze, E
Marmot, MG
Smith, GD
[J]. INTERNATIONAL JOURNAL OF OBESITY, 2005, 29 (10) : 1267 - 1274
[6] Dietary patterns and their correlates among middle-aged and elderly Chinese men: a report from the Shanghai Men's Health Study
Cai, Hui
Zheng, Wei
Xiang, Yong-Bing
Xu, Wang Hong
Yang, Gong
Li, Honglan
Shu, Xiao Ou
[J]. BRITISH JOURNAL OF NUTRITION, 2007, 98 (05) : 1006 - 1013
[7] The American Cancer Society cancer prevention study II nutrition cohort - Rationale, study design, and baseline characteristics
Calle, EE
Rodriguez, C
Jacobs, EJ
Almon, ML
Chao, A
McCullough, ML
Feigelson, HS
Thun, MJ
[J]. CANCER, 2002, 94 (09) : 2490 - 2501
[8] Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults
Calle, EE
Rodriguez, C
Walker-Thurmond, K
Thun, MJ
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (17) : 1625 - 1638
[9] The Nurses' Health Study: Lifestyle and health among women
Colditz, GA
Hankinson, SE
[J]. NATURE REVIEWS CANCER, 2005, 5 (05) : 388 - 396
[10] INSULIN REGULATION OF INSULIN-LIKE GROWTH-FACTOR BINDING PROTEIN-1 IN OBESE AND NONOBESE HUMANS
CONOVER, CA
LEE, PDK
KANALEY, JA
CLARKSON, JT
JENSEN, MD
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1992, 74 (06) : 1355 - 1360

← 1 2 3 4 5 6 →