Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin

被引：182

作者：

Giddings, KS

Zhao, J

Sims, PJ

Tweten, RK ^{[1
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK 73104 USA

[2] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2004年 / 11卷 / 12期

关键词：

D O I：

10.1038/nsmb862

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cholesterol is believed to serve as the common receptor for the cholesterol-dependent cytolysins (CDCs). One member of this toxin family, Streptococcus intermedius intermedilysin (ILY), exhibits a narrow spectrum of cellular specificity that is seemingly inconsistent with this premise. We show here that ILY, via its domain 4 structure, binds to the glycosyl-phosphatidylinositol-linked membrane protein human CD59 (huCD59). CD59 is an inhibitor of the membrane attack complex of human complement. ILY specifically binds to huCD59 via residues that are the binding site for the C8alpha and C9 complement proteins. These studies provide a new model for the mechanism of cellular recognition by a CDC.

引用

页码：1173 / 1178

页数：6

共 41 条

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