VEGF/PLGF induces leukemia cell migration via P38/ERK1/2 kinase pathway, resulting in Rho GTPases activation and caveolae formation

被引：35

作者：

Casalou, C. ^{[1
]}

Fragoso, R.

Nunes, J. F. M.

Dias, S.

机构：

[1] Inst Potugues Oncol Francisco Gentil, Ctr Invest Patobiol Mol, Angiogenesis Lab, Lisbon, Portugal

[2] Inst Portugues Oncol Francisco Gentil, Pathol Lab, Lisbon, Portugal

[3] Gulbenkian Inst Sci, Angiogenesis Lab, Oeiras, Portugal

[4] CIPM, Fac Med, Inst Mol Med, Lisbon, Portugal

来源：

LEUKEMIA | 2007年 / 21卷 / 07期

关键词：

D O I：

10.1038/sj.leu.2404668

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：1590 / 1594

页数：6

共 9 条

[1] Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes [J].

Bellamy, WT ;

Richter, L ;

Sirjani, D ;

Roxas, C ;

Glinsmann-Gibson, B ;

Frutiger, Y ;

Grogan, TM ;

List, AF .

BLOOD, 2001, 97 (05) :1427-1434

[2] Identification of peptide and protein ligands for the caveolin-scaffolding domain - Implications for the interaction of caveolin with caveolae-associated proteins [J].

Couet, J ;

Li, SW ;

Okamoto, T ;

Ikezu, T ;

Lisanti, MP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (10) :6525-6533

[3] Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration [J].

Dias, S ;

Hattori, K ;

Zhu, ZP ;

Heissig, B ;

Choy, M ;

Lane, W ;

Wu, Y ;

Chadburn, A ;

Hyjek, E ;

Gill, M ;

Hicklin, DJ ;

Witte, L ;

Moore, MAS ;

Rafii, S .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (04) :511-521

[4] VEGF165 promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition [J].

Dias, S ;

Shmelkov, SV ;

Lam, G ;

Rafii, S .

BLOOD, 2002, 99 (07) :2532-2540

[5] VEGFR-1 (FLT-1) activation modulates acute lymphoblastic leukemia localization and survival within the bone marrow, determining the onset of extramedullary disease [J].

Fragoso, R ;

Pereira, T ;

Wu, Y ;

Zhu, ZP ;

Cabeçadas, J ;

Dias, S .

BLOOD, 2006, 107 (04) :1608-1616

[6]

Masson-Gadais B, 2003, CELL STRESS CHAPERON, V8, P37, DOI 10.1379/1466-1268(2003)8<37:IVRFVA>2.0.CO

[7]

[8]

RAUTONEN J, 1988, BLOOD, V71, P989

[9] Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct signaling pathways [J].

Santos, SCR ;

Dias, S .

BLOOD, 2004, 103 (10) :3883-3889

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