S-Adenosylmethionine:: A wolf in sheep's clothing, or a rich man's adenosylcobalamin?

被引：184

作者：

Frey, PA

Magnusson, OT

机构：

[1] Univ Wisconsin, Dept Biochem, Madison, WI 53726 USA

[2] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94702 USA

来源：

CHEMICAL REVIEWS | 2003年 / 103卷 / 06期

关键词：

D O I：

10.1021/cr020422m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The commonly held opinion that the major role of SAM in biology is to serve as a methylating agent has now been seriously challenged. Based on the wide variety of reactions facilitated by this coenzyme, it can be argued that the major role of SAM is to serve as an initiator of various enzymatic radical reactions. This exciting property of SAM has now ushered in a new field in radical enzymology" and will undoubtedly provide new and previously unknown avenues for researchers in the field."

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页码：2129 / 2148

页数：20

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