Pulmonary Macrophages: A New Therapeutic Pathway in Fibrosing Lung Disease?

被引：310

作者：

Byrne, Adam J. ^{[1
]}

Maher, Toby M. ^{[1
,2
]}

Lloyd, Clare M. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Inflammat Repair & Dev Sect, London SW7 2AZ, England

[2] Royal Brompton Hosp, NIHR, Resp Biomed Res Unit, Sydney St, London SW3 6NP, England

来源：

TRENDS IN MOLECULAR MEDICINE | 2016年 / 22卷 / 04期

关键词：

TUMOR-NECROSIS-FACTOR; GROWTH-FACTOR-BETA; ALVEOLAR MACROPHAGES; TGF-BETA; FETAL MONOCYTES; MONONUCLEAR PHAGOCYTES; ACTIVATED MACROPHAGES; TYPE-2; INFLAMMATION; TISSUE MACROPHAGES; CONNECTIVE-TISSUE;

D O I：

10.1016/j.molmed.2016.02.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Pulmonary fibrosis (PF) is a growing clinical problem which can result in breathlessness or respiratory failure and has an average life expectancy of 3 years from diagnosis. Therapeutic options for PF are limited and there is therefore a significant unmet clinical need. The recent resurgent interest in macrophage biology has led to a new understanding of lung macrophage origins, biology, and phenotypes. In this review we discuss fibrotic mechanisms and focus on the role of macrophages during fibrotic lung disease. Data from both human and murine studies are reviewed, highlighting novel macrophage-orientated biomarkers for disease diagnosis and potential targets for future anti-fibrotic therapies.

引用

页码：303 / 316

页数：14

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