Interferon-y is produced by another player of innate immune responses: The interferon-producing killer dendritic cell (IKDC)

被引：21

作者：

Bonmort, Mathieu

Ullrich, Evelyn

Mignot, Gregoire

Jacobs, Benedikt

Chaput, Nathalie

Zitvogel, Laurence

机构：

[1] Inst Gustave Roussy, U805, INSERM, F-94805 Villejuif, France

[2] Univ Paris 11, Fac Paris Sud, Kremelin Bicetre, France

[3] INSERM, CBT 507, Villejuif, France

来源：

BIOCHIMIE | 2007年 / 89卷 / 6-7期

基金：

澳大利亚研究理事会;

关键词：

interferon-gamma; TNF-related apoptosis-inducing ligand; interferon-producing killer dendritic cells; dendritic cells; tumor immunity; c-kit tyrosine kinase inhibitor; imatimb mesylate; interleukin-2;

D O I：

10.1016/j.biochi.2007.04.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interferon-gamma is a key cytokine in tumor immunosurveillance. The recently described interferon-producing killer dendritic cell (IKDC), can be distinguished from other innate effectors by its ability to kill a large variety of tumor cells and to produce high amounts of interferon-gamma after encountering tumors in the absence of exogenous cytokines. The cytotoxic activity of IKDC was unraveled during an efficient immunotherapy combining c-kit tyrosine kinase inhibitors and interleukin-2, and is mediated through tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and interferon type IIR. (C) 2007 Published by Elsevier Masson SAS.

引用

页码：872 / 877

页数：6

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