Cloning and expression pattern of a zebrafish homolog of forkhead activin signal transducer (FAST), a transcription factor mediating Nodal-related signals

被引：7

作者：

Boggetti, B

Argenton, F

Haffter, P

Bianchi, ME

Cotelli, F

Beltrame, M

机构：

[1] Univ Milan, Dipartimento Genet & Biol Microrganismi, I-20133 Milan, Italy

[2] Univ Padua, Dipartimento Biol, I-35131 Padua, Italy

[3] Max Planck Inst Entwicklungsbiol, D-72076 Tubingen, Germany

[4] Ist Sci San Raffaele, DIBIT, I-20132 Milan, Italy

[5] Univ Milan, Dept Biol, I-20133 Milan, Italy

来源：

MECHANISMS OF DEVELOPMENT | 2000年 / 99卷 / 1-2期

关键词：

forkhead activin signal transducer; maternal genes; activin; Nodal; cyc; oep; left-right asymmetry; brain; epithalamus; habenula; winged helix; forkhead domain; Smad;

D O I：

10.1016/S0925-4773(00)00485-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Forkhead activin signal transducer (FAST) is a member of the winged-helix family of DNA-binding proteins that has been implicated in mesoderm induction and left-right axis specification during embryonic development in Xenopus and mouse. We have cloned and characterized a zebrafish FAST homolog. Zebrafish fast is expressed maternally and zygotically. Transcripts start regionalizing and decline in level during gastrulation, During somitogenesis, fast is expressed bilaterally in the lateral plate mesoderm, like its mouse homolog. In addition, zebrafish fast is also expressed bilaterally in the dorsal diencephalon, where the nodal-related cyclops gene is only expressed on the left side. It remains to be demonstrated whether FAST expression in the brain can mediate Nodal-induced asymmetric development, (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：187 / 190

页数：4

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