Biomimetic mineralisation of apatites on Ca2+ activated cellulose templates

被引：40

作者：

Cromme, Peter ^{[1
]}

Zollfrank, Cordt ^{[1
]}

Mueller, Lenka ^{[1
]}

Mueller, Frank A. ^{[1
]}

Greil, Peter ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Mat Sci Glass & Ceram, D-91058 Erlangen, Germany

来源：

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS | 2007年 / 27卷 / 01期

关键词：

biomimetic mineralisation; cellulose; calcium phosphate; simulated body fluid;

D O I：

10.1016/j.msec.2005.11.001

中图分类号：

T [工业技术];

学科分类号：

08 [工学];

摘要：

We investigated the activation of regenerated cellulose 2D model thin films and 3D fabric templates with calcium dihydroxide. The Langmuir-Blodgett (LB) film technique was applied for manufacturing of the model thin films using a trimethylsilyl derivative of cellulose (TMS-cellulose). Regenerated cellulose films were obtained by treating the TMS-cellulose LB-films with hydrochloric acid vapours. For 3D templates, regenerated cellulose fabfics (Lyocell((R))) were used. The regenerated cellulose templates were activated with a Ca(OH)(2)-suspension and subsequently exposed to 1.5 x SBF to induce the in situ formation of biomimetic calcium phosphate phases. FTIR and Raman spectroscopy showed that the Ca(OH)(2) and calcite present from reaction with HCO3- on the template surface were dissolved in the initial stage of exposure to the 1.5 x SBF. After 1 day, the formation of apatitic phases in 1.5 x SBF was observed. According to detailed calculations, high supersaturation levels S in close vicinity to the template surface (S > 16) resulting from the Ca2+ diffusion induced the formation of biomimetic calcium phosphate. The biomimetic calcium phosphates were identified by FTIR and Raman spectroscopy as highly carbonated apatites (HCA) lacking hydroxyl ions. 3D fabric templates of regenerated cellulose covered with a biomimetic coating of apatite might be of particular interest for novel scaffold architectures in bone repair and tissue engineering (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：1 / 7

页数：7

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