Effect of hyperuricemia upon endothelial function in patients at increased cardiovascular risk

被引：210

作者：

Mercuro, G

Vitale, C

Cerquetani, E

Zoncu, S

Deidda, M

Fini, M

Rosano, GMC

机构：

[1] Univ Cagliari, Dept Cardiovasc Sci, Cagliari, Italy

[2] Hosp San Raffaele, Cardiovasc Res Unit, Rome, Italy

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2004年 / 94卷 / 07期

关键词：

D O I：

10.1016/j.amjcard.2004.06.032

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of the present study was to evaluate the effect of increased serum uric acid (UA) levels and their therapeutic reduction with allopurinol on endothelium-dependent dilation in subjects with a high cardiovascular (CV) risk but who were free from clinical CV disease. Patients with hyperuricemia had impaired flow-mediated dilation (FMD) compared with matched controls with normal UA levels and elevated CV risk. Three-month therapy with allopurinol improved FM in hyperuricemic subjects, showing an intrinsic negative effect of elevated UA levels on the arterial wall; conversely, FMD remained unchanged in controls, thus suggesting that the reduction of UA to less than a certain value does not affect endothelial function. (C) 2004 by Excerpta Medical, Inc.

引用

收藏

页码：932 / 935

页数：4

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