Neural stem cell transplantation in ischemic stroke: A role for preconditioning and cellular engineering

被引：123

作者：

Bernstock, Joshua D. ^{[1
,2
]}

Peruzzotti-Jametti, Luca ^{[1
]}

Ye, Daniel ^{[2
]}

Gessler, Florian A. ^{[1
]}

Maric, Dragan ^{[2
]}

Vicario, Nunzio ^{[1
]}

Lee, Yang-Ja ^{[2
]}

Pluchino, Stefano ^{[1
]}

Hallenbeck, John M. ^{[2
]}

机构：

[1] Univ Cambridge, Div Stem Cell Neurobiol, Dept Clin Neurosci, Wellcome Trust Med Res Council Stem Cell Inst, Cambridge, England

[2] NINDS, Stroke Branch, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2017年 / 37卷 / 07期

基金：

英国惠康基金;

关键词：

Ischemic stroke; neural stem cells; preconditioning; cellular engineering; post-translational modifications; PRECURSOR CELLS; FUNCTIONAL RECOVERY; ADULT NEUROGENESIS; CEREBRAL-ISCHEMIA; PROGENITOR CELLS; BRAIN; NEUROPROTECTION; AMELIORATION; MIGRATION; STRIATUM;

D O I：

10.1177/0271678X17700432

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Ischemic stroke continues to be a leading cause of morbidity and mortality throughout the world. To protect and/or repair the ischemic brain, a multitiered approach may be centered on neural stem cell (NSC) transplantation. Transplanted NSCs exert beneficial effects not only via structural replacement, but also via immunomodulatory and/or neurotrophic actions. Unfortunately, the clinical translation of such promising therapies remains elusive, in part due to their limited persistence/survivability within the hostile ischemic microenvironment. Herein, we discuss current approaches for the development of NSCs more amenable to survival within the ischemic brain as a tool for future cellular therapies in stroke.

引用

收藏

页码：2314 / 2319

页数：6

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