Current treatment strategies in elderly patients with metastatic colorectal cancer

被引:9
作者
Arkenau, Hendrik-Tobias [1 ]
Chua, Yu Jo [1 ]
Cunningham, David [1 ]
机构
[1] Royal Marsden Hosp London & Sutton, Dept Med Oncol, Sutton SM2 5PT, Surrey, England
关键词
chemotherapy; 5-fluorouracil; irinotecan; leucovorin; oxaliplatin;
D O I
10.3816/CCC.2007.n.016
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Colorectal cancer (CRC) is one of the most common cancers in the Western world,with > 500,000 new cases diagnosed each year. One of the strongest risk factors for colon cancer is age. The incidence rates rise from 10 in 100,000 at age 40-45 years to 300 in 100,000 at age 75-80 years, with the median age at diagnosis of CRC being 71 years. With the general demographic shift toward an aging population, the number of people aged > 65 years is expected to increase. This article reviews the development of treatment for elderly patients with metastatic CRC, from single-agent fluoropyrimidines to combination therapies.
引用
收藏
页码:508 / 515
页数:8
相关论文
共 55 条
[51]  
TRIMBLE EL, 1994, CANCER, V74, P2208, DOI 10.1002/1097-0142(19941001)74:7+<2208::AID-CNCR2820741737>3.0.CO
[52]  
2-#
[53]   Colorectal cancer screening: Clinical guidelines and rationale [J].
Winawer, SJ ;
Fletcher, RH ;
Miller, L ;
Godlee, F ;
Stolar, MH ;
Mulrow, CD ;
Woolf, SH ;
Glick, SN ;
Ganiats, TG ;
Bond, JH ;
Rosen, L ;
Zapka, JG ;
Olsen, SJ ;
Giardiello, FM ;
Sisk, JE ;
vanAntwerp, R ;
BrownDavis, C ;
Marciniak, DA ;
Mayer, RJ .
GASTROENTEROLOGY, 1997, 112 (02) :594-642
[54]  
Yancik R, 1997, CANCER, V80, P1273, DOI 10.1002/(SICI)1097-0142(19971001)80:7<1273::AID-CNCR13>3.3.CO
[55]  
2-5