Stereoisomeric pyrimidine nucleoside analogues based on the 1,3-dihydrobenzo[c]furan core

被引：34

作者：

Ewing, DF ^{[1
]}

Fahmi, NE ^{[1
]}

Len, C ^{[1
]}

Mackenzie, G ^{[1
]}

Pranzo, A ^{[1
]}

机构：

[1] Univ Hull, Dept Chem, Hull HU6 7RX, N Humberside, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2000年 / 21期

关键词：

D O I：

10.1039/b006417n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new efficient route is described to uracil, thymidine and cytosine derivatives of 1,3-dihydrobenzo[c]furan which are aromatic analogues of the well known antiviral 2',3'-dideoxy-2',3'-didehydronucleosides. These systems contain two chiral centres (corresponding to alpha/beta and D/L centres in a furanose sugar) and a route involving application of the Sharpless asymmetric oxidation methodology allowed access to each of the four stereoisomers of the uracil derivative in enantiomerically pure form.

引用

页码：3561 / 3565

页数：5

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