Synthesis of N,N′,N"-trisubstituted thiourea derivatives and their antagonist effect on the vanilloid receptor

被引：21

作者：

Park, H ^{[1
]}

Park, M

Choi, J

Choi, S

Lee, J

Park, B

Kim, MG

Suh, Y

Cho, H

Oh, U

Lee, J

Kim, HD

Park, YH

Koh, HJ

Lim, KM

Moh, JH

Jew, S

机构：

[1] Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul 151742, South Korea

[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[3] Sookmyung Womens Univ, Coll Pharm, Seoul 140742, South Korea

[4] AmorePacific R&D Ctr, Kyounggi 449900, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(02)01040-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Twenty-seven N,N',N"-trisubstituted thiourea derivatives were prepared. Among them, 1-[3-(4'-hydroxy-3'-methoxy- phenyl)-propyl]-1.3-diphenethyl-thiourea (81, IC50=0.32 muM), showed 2-fold higher antagonistic actively than that of capsazepine (3, IC50 = 0.65 muM) against the,anilloid receptor in a Ca-45(2+)-influx assay. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：601 / 604

页数：4

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