Syntheses, structures, and insulin-like activities of two vanadyl complexes;: [VO(GeG)(H2O)] and [VO(MeM)(H2O)]

被引：38

作者：

Kawabe, K

Tadokoro, M

Kojima, Y ^{[1
]}

Fujisawa, Y

Sakurai, H

机构：

[1] Osaka City Univ, Fac Sci, Dept Chem, Sumiyoshi Ku, Osaka 558, Japan

[2] Kyoto Pharmaceut Univ, Dept Analyt & Bioinorgan Chem, Yamashima Ku, Kyoto 607, Japan

来源：

CHEMISTRY LETTERS | 1998年 / 01期

关键词：

D O I：

10.1246/cl.1998.9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We prepared [VO(GeG)(H2O)] and [VO(MeM)(H2O)] by a reaction of VOSO4 with GeG and MeM. X-ray analyses of the complexes showed that a tetradentate ligand (GeG or MeM), an oxygen atom, and a water molecule were coordinated with the vanadium(IV) ion forming distorted octahedral geometries. In in vitro evaluation using isolated rat adipocytes, VO(GeG) (IC50 = 0.42 mM) was found to be more active at lower concentrations than VO(MeM) (IC50 = 17.0 mM) and VOSO4 (IC50 = 6.0 mM) in terms of IC50 values, 50% inhibition concentration of the FFA release from adipocytes.

引用

页码：9 / 10

页数：2

共 10 条

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[2]

CHASTEEN ND, 1983, STRUCT BOND, V53, P105

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