Dermabrasion for prophylaxis and treatment of actinic keratoses

BACKGROUND. After dermabrasion, patients with actinic keratoses remain free of new lesions for many years. This clinical effect has been alluded to for 40 years in the dermatologic literature. However, there has been no consensus on how long this clinical benefit actually lasts. OBJECTIVE. To ascertain the longevity of the beneficial effect of dermabrasion, clinical records of patients who underwent this procedure for treatment of actinic keratosis were reviewed. METHOD. Retrospective review. RESULTS. A total Of 23 such patients with at least 2 years good clinical follow-up were identified. Their ages ranged from 33 to 76 years. One year after dermabrasion, 96% remained free of new actinic keratoses. The benefits of dermabrasion gradually diminished with 83% clear at 2 years, 79% at 3 years, 64% at 4 years, and 54% at 5 years. The average time after dermabrasion before the appearance of one actinic keratoses was 4 years (median, 4.5 years). Dermabrasion, however did not prevent the appearance of basal cell carcinomas in the perinasal area. CONCLUSION. Dermabrasion provides long-term effective prophylaxis against actinic keratoses and presumably squamous cell carcinomas. The benefits last for an average of 4 years before even one new actinic keratosis reappears. Cryosurgery, 5-Fluorouracil, and chemical peels result in much shorter prophylaxis. Dermabrasion is the most effective modality for prevention of new actinic keratoses.