Determination of Jasminoidin in Rabbit Plasma for the Pharmacokinetic Investigation after Single Dose Oral Administration of Gardenia jasminoides Ellis and Gardenia jasminoides Ellis Coupling Coptis chinensis Franch Extracts

被引：9

作者：

Nan, Yefei ^{[1
]}

Zhao, Xinfeng ^{[1
]}

Wei, Lusha ^{[1
]}

Wang, Hongfei ^{[1
]}

Xiao, Chaoni ^{[1
]}

Zheng, Xiaohui ^{[1
]}

机构：

[1] NW Univ Xian, Coll Life Sci, Xian 710069, Peoples R China

来源：

CHROMATOGRAPHIA | 2010年 / 71卷 / 11-12期

基金：

中国科学院西部之光基金; 中国国家自然科学基金;

关键词：

Column liquid chromatography-mass spectrometry; Pharmacokinetic study; Gardenia jasminoides Ellis; RATS; BIOAVAILABILITY; GENIPOSIDE; ISCHEMIA;

D O I：

10.1365/s10337-010-1572-3

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

A simple, sensitive and rapid method for the analysis of jasminoidin in rabbit plasma by liquid chromatography coupled to tandem mass spectrometry was developed. Detection was by positive ion electrospray ionization in multiple reactions monitoring mode. The method included a chromatographic run of 5.0 min using a C(18) analytical column and the calibration curve was linear over the concentration range of 0.5-2,000 ng mL(-1) with a correlation coefficient R of 0.998 or better. The intra- and inter-day precision ranged from 3.4 to 5.6% and 4.3 to 8.2%. The intra- and inter-day assay accuracy was between -7.4 and 8.6%. The method was successfully applied for the pharmacokinetic study on jasminoidin in rabbit after a single dose oral administration of Gardenia jasminoides Ellis (Gardenia) and Gardenia coupling Coptis chinensis Franch (Coptidis) extracts.

引用

页码：1031 / 1037

页数：7

共 20 条

[1]

Co-administration of sirolimus alters tacrolimus pharmacokinetics in a dose-dependent manner in adult renal transplant recipients [J].