Botulinum Toxin to Improve Results in Cleft Lip Repair: A Double-Blinded, Randomized, Vehicle-Controlled Clinical Trial

被引:70
作者
Chang, Chun-Shin [1 ,3 ]
Wallace, Christopher Glenn [3 ]
Hsiao, Yen-Chang [3 ]
Chang, Chee-Jen [2 ]
Chen, Philip Kuo-Ting [3 ]
机构
[1] Chang Gung Univ, Coll Engn, Grad Inst Chem & Mat Engn, Taoyuan, Taiwan
[2] Chang Gung Univ, Sch Med, Grad Inst Clin Med Sci, Taoyuan, Taiwan
[3] Chang Gung Mem Hosp, Craniofacial Res Ctr, Dept Plast Surg, Dept Med Res, Taoyuan, Taiwan
关键词
SCAR FORMATION; FACIAL WOUNDS;
D O I
10.1371/journal.pone.0115690
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];
摘要
Background: Most patients with facial scarring would value even a slight improvement in scar quality. Botulinum toxin A is widely used to alleviate facial dynamic rhytides but is also believed to improve scar quality by reducing wound tension during healing. The main objective was to assess the effect of Botulinum toxin on scars resultant from standardized upper lip wounds. Methods: In this double-blinded, randomized, vehicle-controlled, prospective clinical trial, 60 consecutive consenting adults undergoing cleft lip scar revision (CLSR) surgery between July 2010 and March 2012 were randomized to receive botulinum toxin A (n=30) or vehicle (normal saline; n=30) injections into the subjacent orbicularis oris muscle immediately after wound closure. Scars were independently assessed at 6-months follow-up in blinded fashion using: Vancouver Scar Scale (VSS), Visual Analogue Scale (VAS) and photographic plus ultrasound measurements of scar widths. Results: 58 patients completed the trial. All scar assessment modalities revealed statistically significantly better scars in the experimental than the vehicle-control group. Conclusion: Quality of surgical upper lip scars, which are oriented perpendicular to the direction of pull of the underlying orbicularis oris muscle, is significantly improved by its temporary paralysis during wound healing.
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收藏
页数:12
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