Hepatitis C virus infection and mutations of mannose-binding lectin gene MBL

被引：75

作者：

Matsushita, M

Hijikata, M

Ohta, Y

Iwata, K

Matsumoto, M

Nakao, K

Kanai, K

Yoshida, N

Baba, K

Mishiro, S

机构：

[1] Toshiba Gen Hosp, Dept Med Sci, Shinagawa Ku, Tokyo 1408522, Japan

[2] Toshiba Gen Hosp, Dept Internal Med, Tokyo 1408522, Japan

[3] Toshiba Gen Hosp, Multiphas Hlth Screening Ctr, Tokyo 1408522, Japan

[4] Toshiba Gen Hosp, Cent Clin Lab, Tokyo 1408522, Japan

来源：

ARCHIVES OF VIROLOGY | 1998年 / 143卷 / 04期

关键词：

D O I：

10.1007/s007050050320

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We assessed the genetic polymorphism of mannose-binding lectin (MBL) in 93 patients with chronic hepatitis C (45 responders and 48 nonresponders to interferon) and 218 healthy controls. Mutant allele was identified only at codon 54 (Gly --> Asp), leading to three genotypes (54 m/m, 54 W/m, and 54 W/W). Frequency of 54 m/m was significantly lower in interferon-responders (2.2%), compared to those in nonresponders (14.6%) and controls (10.6%): p<0.05. Our results suggest that homozygous carriage of the variant allele of codon 54 of MBL may predict poor response to interferon in chronic hepatitis C patients.

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收藏

页码：645 / 651

页数：7

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